Bensadoun A, Kompiang I P
Fed Proc. 1979 Nov;38(12):2622-6.
Intravenous injections of anti-lipoprotein lipase serunis quantitatively block the catabolism of very low density lipoprotein (VLDL) and portomicron triglyceride and specifically inhibit triglyceride transport into ovarian follicles. The immunological studies presented provide information on the site of action of lipoprotein lipase (LPL). In the anti-LPL serum-treated animals initial plasma triglyceride accumulation occurs at the time of antiserum injection. This instantaneous inhibition of triglyceride removal provides direct evidence that the functional LPL responsible for VLDL and portomicron triglyceride hydrolysis is located in sites within the plasma compartment readily accessible to immunoglobulins. In vitro immunological studies show that the adipose, heart, ovarian, and liver LPL share common immunological determinants. Biochemical studies on highly purified heart and adipose LPL suggest that these enzymes have identical protein moieties.
静脉注射抗脂蛋白脂肪酶血清可定量阻断极低密度脂蛋白（VLDL）和前β-脂蛋白甘油三酯的分解代谢，并特异性抑制甘油三酯转运至卵巢卵泡。所呈现的免疫学研究提供了有关脂蛋白脂肪酶（LPL）作用位点的信息。在抗LPL血清处理的动物中，初始血浆甘油三酯积累发生在抗血清注射时。这种对甘油三酯清除的即时抑制提供了直接证据，表明负责VLDL和前β-脂蛋白甘油三酯水解的功能性LPL位于血浆隔室内易于被免疫球蛋白接近的位点。体外免疫学研究表明，脂肪、心脏、卵巢和肝脏的LPL具有共同的免疫决定簇。对高度纯化的心脏和脂肪LPL的生化研究表明，这些酶具有相同的蛋白质部分。
