Etienne J, Debray J
Pathol Biol (Paris). 1980 Mar;28(3):193-6.
Lipoprotein lipase (LPL) is an enzyme which hydrolyses triglycerides especially VLDL and chylomicrons triglycerides. The measurement of LPL can be of interest in clinical biochemistry. There is no LPL in blood circulation, but it is possible to release it by heparin intravenous injection. However, heparin releases also other enzymes, particularly hepatic triglyceride lipase (HTGL). It is then post-heparin lipolytic activity (PHLA) which is determined. It is possible to measure separately LPL and HTGL, by using antibodies or inhibitors so chosen to be specific to one or the other enzyme. The main variations of LPL and HTGL in various diseases or treatments at present known are reported. LPL has also been recently involved in atherosclerosis pathogeny.
脂蛋白脂肪酶（LPL）是一种可水解甘油三酯，尤其是极低密度脂蛋白（VLDL）和乳糜微粒甘油三酯的酶。LPL的测定在临床生物化学中具有重要意义。血液循环中不存在LPL，但通过静脉注射肝素可将其释放出来。然而，肝素也会释放其他酶，特别是肝甘油三酯脂肪酶（HTGL）。因此测定的是肝素后脂解活性（PHLA）。通过使用特意选择的对其中一种酶具有特异性的抗体或抑制剂，可以分别测定LPL和HTGL。本文报道了目前已知的LPL和HTGL在各种疾病或治疗中的主要变化情况。最近LPL也被认为与动脉粥样硬化的发病机制有关。
