Bagdade J, Yee E, Pykalisto O J
Horm Metab Res. 1978 Sep;10(5):443-6. doi: 10.1055/s-0028-1093410.
In order to determine the effects of parathyroid hormone on triglyceride transport, male Sprague-Dawley rats were injected with parathyroid extract for eight days and triglyceride secretion rates (TGSR) and adipose tissue lipoprotein lipase (LPL) activity were determined. Parathyroid hormone-treated rats demonstrated significantly lower (p less than .005) TGSR in the basal overnight fasted state 15 hours after the previous injection, but this effect on TGSR was not apparent 3 hours after PTE injection when the rats were allowed to eat. In contrast, LPL activity was significantly reduced in the PTH-treated animals at 3 hours and no effect was apparent on this index of triglyceride removal at 15 hours. These findings suggest that parathyroid hormone may exert independent influences on triglyceride production and removal and thus may alter triglyceride homeostasis in conditions in which parathyroid hormone levels are abnormally increased.
为了确定甲状旁腺激素对甘油三酯转运的影响，给雄性斯普拉格-道利大鼠注射甲状旁腺提取物，持续八天，并测定甘油三酯分泌率（TGSR）和脂肪组织脂蛋白脂肪酶（LPL）活性。在前一次注射15小时后，处于基础过夜禁食状态的甲状旁腺激素处理组大鼠的TGSR显著降低（p小于0.005），但当大鼠进食时，在注射甲状旁腺提取物3小时后，甲状旁腺激素对TGSR的这种影响并不明显。相反，在3小时时，甲状旁腺激素处理组动物的LPL活性显著降低，在15小时时，对甘油三酯清除的这一指标没有明显影响。这些发现表明，甲状旁腺激素可能对甘油三酯的产生和清除产生独立影响，因此在甲状旁腺激素水平异常升高的情况下，可能会改变甘油三酯的稳态。
