普通狨猴（Callithrix jacchus）接种登革病毒后血液学和血清生化参数的变化。
Changes in hematological and serum biochemical parameters in common marmosets (Callithrix jacchus) after inoculation with dengue virus.
作者信息
Omatsu Tsutomu, Moi Meng Ling, Takasaki Tomohiko, Nakamura Shinichiro, Katakai Yuko, Tajima Shigeru, Ito Mikako, Yoshida Tomoyuki, Saito Akatsuki, Akari Hirofumi, Kurane Ichiro
机构信息
Department of Virology I, National Institute of Infectious Diseases, Tokyo, Japan.
出版信息
J Med Primatol. 2012 Oct;41(5):289-96. doi: 10.1111/j.1600-0684.2012.00552.x. Epub 2012 Jul 9.
BACKGROUND
Marmosets are susceptible to dengue virus (DENV) infection. However, blood parameter data and clinical signs of DENV-infected marmosets are limited.
METHODS
Blood hematological and serum biochemical values were obtained from twelve DENV-inoculated and four mock-infected marmosets. Additionally, body temperature and activity level were determined.
RESULTS
Five DENV-inoculated marmosets demonstrated thrombocytopenia, nine demonstrated leucopenia, and five demonstrated an increase in the levels of AST, ALT, LDH, and BUN. Additionally, seven DENV-inoculated marmosets demonstrated clinical signs including fever and decreases in activity. None of the four mock-inoculated marmosets demonstrated changes in either hematological or biochemical parameters.
CONCLUSIONS
Marmosets inoculated with DENV exhibited clinical signs and changes in hematological and biochemical parameters. The results suggest that blood parameter data and clinical signs could potentially be useful markers for understanding the progress of DENV infection in studies using marmosets.
背景
狨猴易感染登革病毒（DENV）。然而，关于感染DENV的狨猴的血液参数数据和临床症状的报道有限。
方法
从12只接种DENV和4只模拟感染的狨猴身上获取血液血液学和血清生化值。此外，还测定了体温和活动水平。
结果
5只接种DENV的狨猴出现血小板减少，9只出现白细胞减少，5只的AST、ALT、LDH和BUN水平升高。此外，7只接种DENV的狨猴出现了包括发热和活动减少在内的临床症状。4只模拟接种的狨猴均未出现血液学或生化参数的变化。
结论
接种DENV的狨猴表现出临床症状以及血液学和生化参数的变化。结果表明，在使用狨猴的研究中，血液参数数据和临床症状可能是了解DENV感染进程的有用指标。
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