Herron Ian C T, Laws Thomas R, Nelson Michelle
CBR Division, Defence Science and Technology Laboratory (Dstl), Salisbury, United Kingdom.
Front Cell Infect Microbiol. 2024 Feb 23;14:1340017. doi: 10.3389/fcimb.2024.1340017. eCollection 2024.
Animal models of infectious disease often serve a crucial purpose in obtaining licensure of therapeutics and medical countermeasures, particularly in situations where human trials are not feasible, i.e., for those diseases that occur infrequently in the human population. The common marmoset (), a Neotropical new-world (platyrrhines) non-human primate, has gained increasing attention as an animal model for a number of diseases given its small size, availability and evolutionary proximity to humans. This review aims to (i) discuss the pros and cons of the common marmoset as an animal model by providing a brief snapshot of how marmosets are currently utilized in biomedical research, (ii) summarize and evaluate relevant aspects of the marmoset immune system to the study of infectious diseases, (iii) provide a historical backdrop, outlining the significance of infectious diseases and the importance of developing reliable animal models to test novel therapeutics, and (iv) provide a summary of infectious diseases for which a marmoset model exists, followed by an in-depth discussion of the marmoset models of two studied bacterial infectious diseases (tularemia and melioidosis) and one viral infectious disease (viral hepatitis C).
传染病动物模型在治疗药物和医学对策的许可获取方面常常发挥着关键作用，尤其是在人体试验不可行的情况下，即针对那些在人类群体中罕见的疾病。普通狨猴（）是一种新热带地区的新世界（阔鼻猴类）非人灵长类动物，鉴于其体型小、易于获取且与人类在进化上亲缘关系较近，作为多种疾病的动物模型受到了越来越多的关注。本综述旨在：（i）通过简要概述普通狨猴目前在生物医学研究中的应用方式，讨论其作为动物模型的优缺点；（ii）总结和评估狨猴免疫系统与传染病研究相关的方面；（iii）提供一个历史背景，概述传染病的重要性以及开发可靠动物模型以测试新型治疗方法的重要性；（iv）总结存在狨猴模型的传染病，随后深入讨论两种已研究的细菌性传染病（兔热病和类鼻疽）和一种病毒性传染病（丙型病毒性肝炎）的狨猴模型。
