Department of Pharmacy, Mayo Clinic College of Medicine, Rochester, MN 55905, USA.
Pain Med. 2012 Aug;13(8):1034-9. doi: 10.1111/j.1526-4637.2012.01434.x. Epub 2012 Jul 9.
The primary aim of this study was to determine the effects of spouse or significant other solicitous responses on morphine equivalent dose among adults with chronic pain.
Retrospective design.
Multidisciplinary pain rehabilitation center.
The cohort included 466 consecutively admitted patients who had a spouse or significant other and were using daily opioids. Intervention. Three-week outpatient pain rehabilitation program.
Solicitous subscale of the Multidimensional Pain Inventory and morphine equivalent dose upon admission.
The mean solicitous subscale score and morphine equivalent dose were 49.8 (standard deviation [SD] = 8.7) and 118mg/day (SD =149), respectively. Univariate linear regression analysis showed that greater subscale scores were associated with greater doses of opioids (P = 0.007). In a multivariate model adjusted for age, sex, ethnicity, years of education, employment status, pain duration, depression, and pain severity, the association retained significance (P = 0.007).
These findings suggest solicitous responses from a spouse or significant other may have an important influence on opioid dose among adults with chronic pain.
本研究的主要目的是确定配偶或重要他人的关心反应对慢性疼痛成人吗啡等效剂量的影响。
回顾性设计。
多学科疼痛康复中心。
队列包括 466 名连续入院的患者，他们有配偶或重要他人，并且每天使用阿片类药物。
为期 3 周的门诊疼痛康复计划。
多维疼痛量表的关心亚量表和入院时的吗啡等效剂量。
关心亚量表评分和吗啡等效剂量的平均值分别为 49.8（标准差 [SD]=8.7）和 118mg/天（SD=149）。单变量线性回归分析表明，亚量表评分越高，阿片类药物剂量越大（P=0.007）。在调整年龄、性别、种族、受教育年限、就业状况、疼痛持续时间、抑郁和疼痛严重程度的多变量模型中，这种关联仍然具有显著性（P=0.007）。
这些发现表明，配偶或重要他人的关心反应可能对慢性疼痛成人的阿片类药物剂量有重要影响。
