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化疗在IIb期鼻咽癌中的作用。

Role of chemotherapy in stage IIb nasopharyngeal carcinoma.

作者信息

Pan Xin-Bin, Zhu Xiao-Dong

机构信息

Department of Radiation Oncology, Cancer Hospital of Guangxi Medical University, Nanning, Guangxi 530021, P. R. China.

出版信息

Chin J Cancer. 2012 Dec;31(12):573-8. doi: 10.5732/cjc.011.10433. Epub 2012 Jul 4.

DOI:10.5732/cjc.011.10433
PMID:22776232
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3777455/
Abstract

The efficacy of neoadjuvant chemotherapy and adjuvant chemotherapy on stage IIb nasopharyngeal carcinoma(NPC) remains unclear. Conventional two-dimensional radiotherapy combined with concurrent chemotherapy can improve the overall survival, progression-free survival, recurrence-free survival, and distant metastasis-free survival of patients with stage IIb NPC. Intensity-modulated radiotherapy without concurrent chemotherapy also provides good outcomes for patients with stage IIb NPC. This article summarizes the features of stage IIb NPC and reviews the role of chemotherapy in this subgroup of NPC.

摘要

新辅助化疗和辅助化疗对IIb期鼻咽癌（NPC）的疗效仍不明确。传统二维放疗联合同期化疗可提高IIb期NPC患者的总生存期、无进展生存期、无复发生存期和无远处转移生存期。不进行同期化疗的调强放疗也可为IIb期NPC患者带来良好疗效。本文总结了IIb期NPC的特点，并综述了化疗在该亚组NPC中的作用。

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本文引用的文献

1
Concurrent chemoradiotherapy vs radiotherapy alone in stage II nasopharyngeal carcinoma: phase III randomized trial.同期放化疗与单纯放疗治疗 II 期鼻咽癌的随机 III 期临床试验。
J Natl Cancer Inst. 2011 Dec 7;103(23):1761-70. doi: 10.1093/jnci/djr432. Epub 2011 Nov 4.
2
Role of chemoradiotherapy in intermediate prognosis nasopharyngeal carcinoma.放化疗在中危预后鼻咽癌中的作用。
Oral Oncol. 2011 May;47(5):408-13. doi: 10.1016/j.oraloncology.2011.03.008. Epub 2011 Apr 2.
3
Long-term outcomes of early-stage nasopharyngeal carcinoma patients treated with intensity-modulated radiotherapy alone.单纯调强放疗治疗早期鼻咽癌患者的长期疗效。
Int J Radiat Oncol Biol Phys. 2012 Jan 1;82(1):327-33. doi: 10.1016/j.ijrobp.2010.09.011. Epub 2010 Oct 29.
4
Intensity-modulated radiation therapy without concurrent chemotherapy for stage IIb nasopharyngeal cancer.调强放疗不联合化疗治疗Ⅱb 期鼻咽癌。
Am J Clin Oncol. 2010 Jun;33(3):294-9. doi: 10.1097/COC.0b013e3181d2edab.
5
Whole-field simultaneous integrated-boost intensity-modulated radiotherapy for patients with nasopharyngeal carcinoma.适形调强同步推量放疗治疗鼻咽癌。
Int J Radiat Oncol Biol Phys. 2010 Jan 1;76(1):138-45. doi: 10.1016/j.ijrobp.2009.01.084.
6
Treatment outcomes after radiotherapy alone for patients with early-stage nasopharyngeal carcinoma.早期鼻咽癌患者单纯放疗后的治疗结果。
Int J Radiat Oncol Biol Phys. 2009 Jul 15;74(4):1070-6. doi: 10.1016/j.ijrobp.2008.09.008. Epub 2009 Feb 21.
7
Retropharyngeal nodal metastasis related to higher rate of distant metastasis in patients with N0 and N1 nasopharyngeal cancer.在N0和N1期鼻咽癌患者中，咽后淋巴结转移与远处转移率较高相关。
Head Neck. 2009 Apr;31(4):468-74. doi: 10.1002/hed.21008.
8
Prognostic influence of parapharyngeal extension in nasopharyngeal carcinoma.
Acta Otolaryngol. 2008 Jul;128(7):790-8. doi: 10.1080/00016480701714269.
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Parapharyngeal extension of nasopharyngeal carcinoma: still a significant factor in era of modern radiotherapy?鼻咽癌的咽旁扩展：在现代放疗时代仍是一个重要因素吗？
Int J Radiat Oncol Biol Phys. 2008 Nov 15;72(4):1082-9. doi: 10.1016/j.ijrobp.2008.02.006. Epub 2008 Apr 12.
10
Treatment outcomes for radiotherapy alone are comparable with neoadjuvant chemotherapy followed by radiotherapy in early-stage nasopharyngeal carcinoma.早期鼻咽癌单纯放疗的治疗效果与新辅助化疗后放疗相当。
Laryngoscope. 2008 Apr;118(4):663-70. doi: 10.1097/MLG.0b013e3181626cfe.