Department of Radiation Oncology, Centre Antoine Lacassagne - Université Nice Sophia Antipolis, Nice, France.
Crit Rev Oncol Hematol. 2013 Feb;85(2):193-205. doi: 10.1016/j.critrevonc.2012.06.003. Epub 2012 Jul 7.
There is worldwide increased in obesity prevalence and statistical almost half of United-States, including children, could be obese by 2050. Obesity in cancer patients is a major issue in oncology because weight gain and obesity account for approximately 20% of all cancer cases. Indeed, increased obesity is linked with higher risk of various types of cancer and a poorer survival. Although biological mechanisms underlying how obesity causes an increased risk of cancer are suggested, overweight as a putative direct cause of death is still debated. Numerous confounding factors may impact on survival, including comorbidities and imaging limitations. Moreover, difficulties to achieve the standard oncologic care with surgery, chemotherapy and/or radiation may also be concerned. Herein, we examined the specific features and potential adaptation of the cancer management in overweighed patients. Then, we reviewed how implicated molecular pathways may provide new strategies to decrease cancer risk and predict toxicities in an increasingly obese population.
全球肥胖症的患病率不断上升，据统计，到 2050 年，美国几乎一半的人（包括儿童）可能会肥胖。癌症患者的肥胖是肿瘤学中的一个主要问题，因为体重增加和肥胖占所有癌症病例的约 20%。事实上，肥胖的增加与各种类型癌症的风险增加和生存率降低有关。虽然已经提出了肥胖导致癌症风险增加的潜在生物学机制，但超重作为直接死亡原因仍存在争议。许多混杂因素可能会影响生存率，包括合并症和影像学限制。此外，超重患者在接受手术、化疗和/或放疗等标准肿瘤治疗方面可能也存在困难。在此，我们研究了超重患者癌症管理的具体特征和潜在的适应性。然后，我们回顾了相关的分子途径如何为减少肥胖人群的癌症风险和预测毒性提供新的策略。
