多梳蛋白家族及其在调节干细胞发育中的作用。

Polycomb group proteins and their roles in regulating stem cell development.

作者信息

Huang Bing-yang, Pan Xiao-yan, Li Zhi-xin, Wang Zheng-chao, Yu Yong-sheng, Dou Zhao-hua

机构信息

Department of Histology and Embryology, Jilin Medical College, Jilin 132013, China.

出版信息

Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2012 Jun;34(3):281-5. doi: 10.3881/j.issn.1000-503X.2012.03.019.

DOI:10.3881/j.issn.1000-503X.2012.03.019

PMID:22776663

Abstract

Polycomb group (PcG) proteins are a family of epigenetic regulators responsible for the repression of genes in proliferation and differentiation of stem cells. PcG protein complex consists of two important epigenetic regulators: PRC1 (polycomb repressive complex 1) and PRC2 (polycomb repressive complex 2). In order to further understand the functions of PcG proteins in stem cell growth and differentiation, we review the PcG protein composition, PcG protein localization in the target gene, PcG protein recruitment, and the functions of PcG proteins in the development of stem cells.

摘要

多梳蛋白家族（PcG）是一类表观遗传调控因子，负责在干细胞增殖和分化过程中抑制基因表达。PcG蛋白复合物由两种重要的表观遗传调控因子组成：PRC1（多梳抑制复合物1）和PRC2（多梳抑制复合物2）。为了进一步了解PcG蛋白在干细胞生长和分化中的功能，我们综述了PcG蛋白的组成、PcG蛋白在靶基因中的定位、PcG蛋白的募集以及PcG蛋白在干细胞发育中的功能。