Endocrinology and Metabolism Unit, Department of Internal Medicine, Hacettepe University School of Medicine, Hacettepe, 06100 Ankara, Turkey.
Hum Reprod. 2012 Oct;27(10):3067-73. doi: 10.1093/humrep/des232. Epub 2012 Jul 9.
What is the prevalence, phenotype and metabolic features of polycystic ovary syndrome (PCOS) in the same population according to three different diagnostic criteria?
The prevalence of PCOS under National Institutes of Health (NIH), Rotterdam and Androgen Excess and PCOS (AE-PCOS) Society criteria was 6.1, 19.9 and 15.3%, respectively. PCOS carried a 2-fold increased risk of metabolic syndrome regardless of the diagnostic criteria used.
The prevalence rates of PCOS differ depending on the diagnostic criteria used to define the syndrome. The current paper gives the prevalence rates of the component and composite phenotypes of PCOS in the same population and reports similar rates of metabolic syndrome in women with PCOS under contrasting diagnostic criteria.
In this cross-sectional study, 392 women between the ages of 18 and 45 years were analyzed.
When the prevalence of PCOS according to NIH was set to 8% with a precision of 2.2% and confidence interval of 95%, the sample size required for a prevalence survey was found to be 400 subjects. The study was carried out in the General Directorate of Mineral Research and Exploration, a government-based institute, in which the largest number of female staff (n = 527) are employed within a single institute in Ankara, Turkey. The study was performed between 7 December 2009 and 30 April 2010. All female subjects between the ages of 18 and 45 years were invited to participate. Women older than 45 or younger than 18 years, post-menopausal women, women with a history of hysterectomy or bilateral oopherectomy and pregnant women were excluded. Totally, 392 of the employees were recruited for the final analyses.
The prevalence of PCOS under NIH, Rotterdam and AE-PCOS Society criteria were 6.1, 19.9 and 15.3%, respectively. While the prevalence of metabolic syndrome was 6.1% in the whole study group, within the patients diagnosed as PCOS according to NIH, Rotterdam and AE-PCOS Society criteria, it was 12.5, 10.3 and 10.0%, respectively.
BIAS, CONFOUNDING AND OTHER REASONS FOR CAUTION: Even though we have included women working at a single institution with a high response rate for the participation, we cannot exclude potential selection bias due to undetermined differences between our sample and background community. We might have underestimated actual prevalence of metabolic syndrome in PCOS due to lack of oral glucose tolerance test 2 h glucose data.
Current results can be generalized to Caucasian populations and may present variations in other populations according to race and ethnicity.
STUDY FUNDING/COMPETING INTEREST(S): This work was, in part, sponsored by Merck Serono.
Not applicable.
根据三种不同的诊断标准，同一人群中多囊卵巢综合征（PCOS）的患病率、表型和代谢特征是什么？
根据美国国立卫生研究院（NIH）、鹿特丹和雄激素过多与 PCOS 协会（AE-PCOS 协会）的标准，PCOS 的患病率分别为 6.1%、19.9%和 15.3%。无论使用何种诊断标准，PCOS 患者患代谢综合征的风险增加 2 倍。
不同的诊断标准用于定义该综合征时，PCOS 的患病率存在差异。目前的论文给出了同一人群中 PCOS 组成和综合表型的患病率，并报告了在不同的诊断标准下，患有 PCOS 的女性代谢综合征的发生率相似。
在这项横断面研究中，分析了 392 名年龄在 18 至 45 岁之间的女性。
当 NIH 标准下 PCOS 的患病率设定为 8%，精度为 2.2%，置信区间为 95%时，发现患病率调查所需的样本量为 400 例。该研究在土耳其安卡拉的一家政府机构——矿产资源研究和勘探总局进行，该机构内的女性员工数量最多（n=527）。研究于 2009 年 12 月 7 日至 2010 年 4 月 30 日进行。邀请所有年龄在 18 至 45 岁之间的女性参加。排除年龄超过 45 岁或小于 18 岁、绝经后妇女、曾接受过子宫切除术或双侧卵巢切除术的妇女以及孕妇。最后，共有 392 名员工被招募进行最终分析。
根据 NIH、鹿特丹和 AE-PCOS 协会的标准，PCOS 的患病率分别为 6.1%、19.9%和 15.3%。虽然整个研究组的代谢综合征患病率为 6.1%，但根据 NIH、鹿特丹和 AE-PCOS 协会的标准，诊断为 PCOS 的患者中，患病率分别为 12.5%、10.3%和 10.0%。
偏倚、混杂因素和其他注意事项：尽管我们纳入了在单一机构工作、参与率高的女性，但由于我们的样本与背景社区之间存在未确定的差异，我们可能无法排除潜在的选择偏倚。由于缺乏口服葡萄糖耐量试验 2 小时血糖数据，我们可能低估了 PCOS 患者中代谢综合征的实际患病率。
目前的结果可以推广到白种人群，并且可能根据种族和民族在其他人群中出现变化。
研究资金/利益冲突：这项工作部分得到了默克雪兰诺的赞助。
不适用。
