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Recommendations from the 2023 International Evidence-based Guideline for the Assessment and Management of Polycystic Ovary Syndrome.2023 年多囊卵巢综合征评估和管理国际循证指南推荐意见。
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2
Dose Nomogram of Individualization of the Initial Follicle-Stimulating Hormone Dosage for Patients with Polycystic Ovary Syndrome Undergoing IVF/ICSI with the GnRH-Ant Protocol: A Retrospective Cohort Study.个体化起始促卵泡激素剂量在 GnRH 拮抗剂方案 IVF/ICSI 中治疗多囊卵巢综合征患者中的剂量列线图：一项回顾性队列研究。
Adv Ther. 2023 Sep;40(9):3971-3985. doi: 10.1007/s12325-023-02582-2. Epub 2023 Jul 3.
3
AMH predicts miscarriage in non-PCOS but not in PCOS related infertility ART cycles.抗缪勒管激素（AMH）可预测非多囊卵巢综合征（PCOS）相关但不孕不育患者接受辅助生殖技术（ART）周期中的流产。
Reprod Biol Endocrinol. 2023 Apr 5;21(1):35. doi: 10.1186/s12958-023-01087-5.
4
The reference value of anti-Müllerian hormone to diagnose polycystic ovary syndrome is inversely associated with BMI: a retrospective study.抗苗勒管激素的参考值与 BMI 呈负相关，可用于诊断多囊卵巢综合征：一项回顾性研究。
Reprod Biol Endocrinol. 2023 Feb 1;21(1):15. doi: 10.1186/s12958-023-01064-y.
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Impact of body mass index and vitamin D on serum AMH levels and antral follicle count in PCOS.多囊卵巢综合征患者血清 AMH 水平与窦卵泡计数受体重指数和维生素 D 的影响。
Eur Rev Med Pharmacol Sci. 2023 Jan;27(1):179-187. doi: 10.26355/eurrev_202301_30870.
6
Risk factors for clinical pregnancy loss after IVF in women with PCOS.多囊卵巢综合征女性体外受精后临床妊娠丢失的危险因素。
Reprod Biomed Online. 2023 Jan;46(1):107-114. doi: 10.1016/j.rbmo.2022.10.002. Epub 2022 Oct 12.
7
Polycystic ovary syndrome and risk of adverse pregnancy outcomes: a registry linkage study from Massachusetts.多囊卵巢综合征与不良妊娠结局风险：来自马萨诸塞州的注册关联研究。
Hum Reprod. 2022 Oct 31;37(11):2690-2699. doi: 10.1093/humrep/deac210.
8
Serum anti-Müllerian hormone levels are associated with early miscarriage in the IVF/ICSI fresh cycle.血清抗穆勒管激素水平与 IVF/ICSI 新鲜周期中的早期流产有关。
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Association of antimüllerian hormone with polycystic ovarian syndrome phenotypes and pregnancy outcomes of in vitro fertilization cycles with fresh embryo transfer.抗缪勒管激素与多囊卵巢综合征表型及新鲜胚胎移植体外受精周期妊娠结局的相关性。
BMC Pregnancy Childbirth. 2022 Mar 2;22(1):171. doi: 10.1186/s12884-022-04518-0.
10
Elevated Anti-Müllerian Hormone Is an Independent Risk Factor for Preterm Birth Among Patients With Overweight Polycystic Ovary Syndrome.超重多囊卵巢综合征患者血清抗苗勒管激素水平升高是发生早产的独立危险因素。
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多囊卵巢综合征患者血清抗苗勒管激素水平与体重指数的不同组合对妊娠结局的影响

Effect of different combinations of serum antimüllerian hormone levels and body mass index on pregnancy outcomes in women with polycystic ovary syndrome.

作者信息

Niu Yue, Han Xinwei, Xiao Huiying, Miao Ruolan, Ouyang Gege, Wang Qian, Wei Daimin

机构信息

State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health, Shandong University, Jinan, Shandong, China (Niu, Han, Xiao, Miao, Ouyang, and Wei).

National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, Shandong, China (Niu, Han, Xiao, Miao, Ouyang, and Wei).

出版信息

AJOG Glob Rep. 2025 Feb 22;5(2):100461. doi: 10.1016/j.xagr.2025.100461. eCollection 2025 May.

DOI:10.1016/j.xagr.2025.100461
PMID:40162007
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11952798/
Abstract

BACKGROUND

Both antimüllerian hormone and body mass index are associated with the pregnancy outcomes in women with polycystic ovary syndrome undergoing in vitro fertilization.

OBJECTIVE

This study aimed to explore the effect of different combinations of antimüllerian hormone and body mass index on pregnancy outcomes in women with polycystic ovary syndrome undergoing in vitro fertilization.

STUDY DESIGN

This was a post hoc secondary analysis of a multicenter randomized trial. A total of 625 women from 1 center with antimüllerian hormone levels measured before in vitro fertilization treatment were classified into 6 groups: group A (normal weight and low antimüllerian hormone group), group B (normal weight and intermediate antimüllerian hormone group), group C (normal weight and high antimüllerian hormone group), group D (overweight/obese and low antimüllerian hormone group), group E (overweight/obese and intermediate antimüllerian hormone group), and group F (overweight/obese and high antimüllerian hormone group).

RESULTS

After adjustment via multivariate logistic regression, the overweight/obese and high antimüllerian hormone group (group F) had a higher risk of clinical pregnancy miscarriage (adjusted odds ratio, 3.30; 95% confidence interval, 1.35-8.07) than the normal weight and intermediate antimüllerian hormone group (group B). Both the normal weight and high antimüllerian hormone group (group C; adjusted odds ratio, 3.74; 95% confidence interval, 1.06-13.24) and the overweight/obese and high antimüllerian hormone group (group F; adjusted odds ratio, 3.61; 95% confidence interval, 1.05-12.38) had higher risks of ovarian hyperstimulation syndrome than the normal weight and intermediate antimüllerian hormone group (group B).

CONCLUSION

In women with polycystic ovary syndrome, high serum antimüllerian hormone levels were associated with an increased risk of clinical pregnancy miscarriage in women who were overweight/obese but not in those with normal weight.

摘要

背景

抗苗勒管激素和体重指数均与接受体外受精的多囊卵巢综合征女性的妊娠结局相关。

目的

本研究旨在探讨抗苗勒管激素和体重指数的不同组合对接受体外受精的多囊卵巢综合征女性妊娠结局的影响。

研究设计

这是一项对多中心随机试验的事后二次分析。来自1个中心的625名在体外受精治疗前测量了抗苗勒管激素水平的女性被分为6组：A组（体重正常且抗苗勒管激素水平低）、B组（体重正常且抗苗勒管激素水平中等）、C组（体重正常且抗苗勒管激素水平高）、D组（超重/肥胖且抗苗勒管激素水平低）、E组（超重/肥胖且抗苗勒管激素水平中等）和F组（超重/肥胖且抗苗勒管激素水平高）。

结果

经多因素逻辑回归调整后，超重/肥胖且抗苗勒管激素水平高的组（F组）临床妊娠流产风险高于体重正常且抗苗勒管激素水平中等的组（B组）（调整后的优势比为3.30；95%置信区间为1.35 - 8.07）。体重正常且抗苗勒管激素水平高的组（C组；调整后的优势比为3.74；95%置信区间为1.06 - 13.24）和超重/肥胖且抗苗勒管激素水平高的组（F组；调整后的优势比为3.61；95%置信区间为1.05 - 12.38）卵巢过度刺激综合征风险均高于体重正常且抗苗勒管激素水平中等的组（B组）。

结论

在多囊卵巢综合征女性中，如果超重/肥胖，血清抗苗勒管激素水平高与临床妊娠流产风险增加相关，而体重正常者则不然。