Clinical Centre for Urological and Gynecological Disease Diagnosis, Tehran, Iran.
Psychooncology. 2013 Jun;22(6):1242-8. doi: 10.1002/pon.3130. Epub 2012 Jul 9.
The breast cancer (BC) and its treatment (mastectomy, radiotherapy, and chemotherapy) have considerable psychosexual impacts on women's life. This study evaluated sexual functioning, quality of life, and self-esteem in young women with early-stage BC.
A total of 186 women with stage I or II BC and 204 age-matched controls aged 25-45 years were recruited. To be eligible, patients had to be disease-free and sexually active. They also had to have undergone lumpectomy at least 1 year previously and have completed chemotherapy and/or radiotherapy. Subjects completed Female Sexual Function Index, Short Form-36 Health Survey, and Rosenberg Self-Esteem questionnaire. Serum sex hormones were also measured in all subjects.
Of BC patients, 57% experienced lubrication disorder followed by satisfaction disorder in 53.8%, desire disorder in 42.5%, and arousal disorder in 37.0% (all patients vs. healthy controls <0.01). Hormone-treated patients were more likely to report sexual dysfunctions (p = 0.006). The radiotherapy + chemotherapy + hormone therapy was associated with an about sixfold increased risk of lubrication and satisfaction disorders (adjusted odds ratios = 6.4, 95%CI = 4.6-12.6, and adjusted odds ratios = 5.7, 95%CI = 3.4-11.4, respectively). Cancer patients had lower scores for all components of the Short Form-36 Health Survey, except for pain. Levels of self-esteem did not differ significantly between the two groups.
Young lumpectomized BC women reported a marked impairment in sexual functioning and quality of life.
乳腺癌（BC）及其治疗方法（乳房切除术、放疗和化疗）对女性的生活有相当大的心理影响。本研究评估了早期乳腺癌年轻女性的性功能、生活质量和自尊。
共招募了 186 名 I 期或 II 期 BC 女性和 204 名年龄匹配的 25-45 岁对照组。符合条件的患者必须无病且有性生活。他们还必须在至少 1 年前接受过保乳手术，并且已经完成了化疗和/或放疗。研究对象完成了女性性功能指数、36 项简短健康调查问卷和罗森伯格自尊问卷。所有受试者还测量了血清性激素。
在 BC 患者中，57%的人出现润滑障碍，其次是 53.8%的人出现满意度障碍、42.5%的人出现欲望障碍和 37.0%的人出现唤起障碍（所有患者与健康对照组比较均<0.01）。接受激素治疗的患者更有可能报告性功能障碍（p=0.006）。放疗+化疗+激素治疗与润滑和满意度障碍的风险增加约六倍相关（调整后的优势比=6.4，95%CI=4.6-12.6 和调整后的优势比=5.7，95%CI=3.4-11.4）。癌症患者在所有 36 项简短健康调查问卷的组成部分中的得分都较低，除了疼痛。两组的自尊水平没有显著差异。
年轻的保乳乳腺癌女性报告性功能和生活质量明显受损。
