在中国人群中，2型糖尿病易感性基因SLC30A8与精神分裂症之间无关联。
No association between the type 2 diabetes mellitus susceptibility gene, SLC30A8 and schizophrenia in a Chinese population.
作者信息
Zhang Xuan, Guan Song-Lei, Wang Zhen-Qi, You Yang, Sun Shi-Long, Hui Li, Miao Li-Ning, Yu Yaqin, Kosten Thomas R, Zhang Xiang Yang
机构信息
Research Center for Diabetic Complication and Department of Nephrology, the Second Hospital, Jilin University, Changchun, China.
出版信息
Hum Psychopharmacol. 2012 Jul;27(4):392-6. doi: 10.1002/hup.2239. Epub 2012 Jul 9.
BACKGROUND
The co-occurrence of schizophrenia and type 2 diabetes mellitus (T2DM) has been well documented. Recent genome-wide association studies and meta-analyses have shown robust associations of the solute carrier family 30 member 8 (SLC30A8) gene variants with T2DM in various populations. We examined the involvement of the SLC30A8 in the susceptibility to schizophrenia in a Han Chinese population.
METHODS
The SLC30A8 rs13266634 gene polymorphism was genotyped in 837 chronic schizophrenic and 1109 unrelated healthy controls by using a case control design. We also assessed clinical symptoms.
RESULTS
There were no significant differences in the rs13266634 genotype (χ(2) = 1.95, df = 2, p = 0.38) and allele (χ(2) = 0.47, df = 1, p = 0.50) distributions between the patient and control groups. There was no association between rs13266634 and clinical symptoms.
CONCLUSION
The SLC30A8 gene variation does not appear to contribute a genetic basis for the co-occurrence of schizophrenia and T2DM.
背景
精神分裂症与2型糖尿病（T2DM）的共病现象已有充分记录。近期的全基因组关联研究和荟萃分析表明，溶质载体家族30成员8（SLC30A8）基因变异在不同人群中与T2DM存在显著关联。我们在汉族人群中研究了SLC30A8在精神分裂症易感性中的作用。
方法
采用病例对照设计，对837例慢性精神分裂症患者和1109名无亲缘关系的健康对照进行SLC30A8 rs13266634基因多态性基因分型。我们还评估了临床症状。
结果
患者组和对照组之间rs13266634基因型（χ(2) = 1.95，自由度 = 2，p = 0.38）和等位基因（χ(2) = 0.47，自由度 = 1，p = 0.50）分布无显著差异。rs13266634与临床症状之间无关联。
结论
SLC30A8基因变异似乎并非精神分裂症与T2DM共病的遗传基础。
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