Departamento de Química, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria, CEP 97105-900, RS, Brasil.
Environ Toxicol. 2014 Jun;29(6):665-71. doi: 10.1002/tox.21793. Epub 2012 Jul 10.
The present study investigated the effect of diphenyl diselenide [(PhSe)2 ] on metabolic disorders induced by acephate acute exposure in rats. We also investigated a possible mechanism of action of (PhSe)2 against hyperglycemia induced by acephate. (PhSe)2 was administered to rats at a dose of 10 or 30 mg/kg by oral gavage (p.o.) 1 hour prior to acephate administration (140 mg/kg; p.o.). Glucose and corticosterone levels as well as the lipid status were determined in plasma of rats. Cardiovascular risk factors and the atherogenic index were calculated. Glycogen levels as well as tyrosine aminotransferase (TAT) and glucose-6-phosphatase (G6Pase) activities were determined in livers of rats. Cerebral acetylcholinesterase (AChE) activity was assayed. Acephate induced an increase in glucose and corticosterone levels as well as in TAT and G6Pase activities. AChE activity was inhibited by acephate. Triglyceride (TG) levels and the cardiovascular risk factor TG/high-density lipoprotein-cholesterol (HDL) were increased by acephate. (PhSe)2 was effective against the metabolic disorders induced by acephate acute exposure in rats.
本研究探讨了二苯基二硒醚[(PhSe)2]对急性敌百虫暴露诱导的大鼠代谢紊乱的影响。我们还研究了(PhSe)2对抗敌百虫诱导的高血糖的可能作用机制。(PhSe)2 以 10 或 30mg/kg 的剂量通过口服灌胃（p.o.）在敌百虫给药（140mg/kg;p.o.）前 1 小时给予大鼠。测定大鼠血浆中的葡萄糖和皮质酮水平以及脂质状况。计算心血管危险因素和动脉粥样硬化指数。测定大鼠肝脏中的糖原水平以及酪氨酸转氨酶（TAT）和葡萄糖-6-磷酸酶（G6Pase）活性。测定脑乙酰胆碱酯酶（AChE）活性。敌百虫诱导葡萄糖和皮质酮水平以及 TAT 和 G6Pase 活性增加。AChE 活性被敌百虫抑制。敌百虫使甘油三酯（TG）水平和心血管危险因素 TG/高密度脂蛋白胆固醇（HDL）升高。(PhSe)2 对抗急性敌百虫暴露诱导的大鼠代谢紊乱有效。
