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磷酸三钙与骨形态发生蛋白7治疗胫骨骨不连

Management of tibial non-union with tricalcium phosphate and BMP 7.

作者信息

Cubitt Jonathan, McAndrew Andrew

机构信息

Department of Plastic Surgery, Stoke Mandeville Hospital, Aylesbury, UK.

出版信息

BMJ Case Rep. 2010 Sep 20;2010:bcr0220102777. doi: 10.1136/bcr.02.2010.2777.

DOI:10.1136/bcr.02.2010.2777
PMID:22778284
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3027462/
Abstract

We present the case of a 30-year-old woman who was referred with an established tibial non-union with a bone defect following a spiral fracture of the tibia. Initial attempts at union with intramedullary fixation and then autograft were unsuccessful. We achieved union by debriding the fibrous tissue and packing the defect with Bone Morphogenetic Protein 7 (Osigraft, Stryker, UK) and a tricalcium phosphate bone void filler (Calstrux, Stryker, UK). We did not use any additional surgical fixation and the patient was supported in an aircast boot.

摘要

我们报告一例30岁女性病例，该患者因胫骨螺旋形骨折后出现骨不连并有骨缺损而前来就诊。最初尝试采用髓内固定并随后进行自体骨移植，但均未成功。我们通过清除纤维组织并用骨形态发生蛋白7（Osigraft，史赛克公司，英国）和磷酸三钙骨缺损填充剂（Calstrux，史赛克公司，英国）填充缺损实现了骨愈合。我们未使用任何额外的手术固定，患者使用空气支具进行辅助。

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本文引用的文献

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[Treatment of traumatic bone defect with graft material of allogenic cancellous combined with autologous red marrow].同种异体松质骨联合自体红骨髓移植材料治疗创伤性骨缺损
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2008 Oct;22(10):1251-4.
2
Tissue engineering of bone: material and matrix considerations.骨组织工程：材料与基质考量
J Bone Joint Surg Am. 2008 Feb;90 Suppl 1:36-42. doi: 10.2106/JBJS.G.01260.
3
Clinical effectiveness and cost-effectiveness of bone morphogenetic proteins in the non-healing of fractures and spinal fusion: a systematic review.骨形态发生蛋白在骨折不愈合和脊柱融合中的临床疗效及成本效益：一项系统评价
Health Technol Assess. 2007 Aug;11(30):1-150, iii-iv. doi: 10.3310/hta11300.
4
Current and future clinical applications of bone morphogenetic proteins in orthopaedic trauma surgery.骨形态发生蛋白在骨科创伤手术中的当前及未来临床应用
Int Orthop. 2007 Dec;31(6):721-7. doi: 10.1007/s00264-007-0424-8. Epub 2007 Aug 1.
5
Recombinant human BMP-2 and allograft compared with autogenous bone graft for reconstruction of diaphyseal tibial fractures with cortical defects. A randomized, controlled trial.重组人骨形态发生蛋白-2与同种异体骨移植对比自体骨移植用于重建伴有皮质缺损的胫骨干骨折：一项随机对照试验。
J Bone Joint Surg Am. 2006 Jul;88(7):1431-41. doi: 10.2106/JBJS.E.00381.
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Repair of alveolar clefts with recombinant human bone morphogenetic protein (rhBMP-2) in patients with clefts.重组人骨形态发生蛋白（rhBMP - 2）用于腭裂患者牙槽嵴裂修复
J Craniofac Surg. 2005 Sep;16(5):778-89. doi: 10.1097/01.scs.0000166802.49021.01.
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Repair of a resistant tibial non-union with a recombinant bone morphogenetic protein-7 (rh-BMP-7).使用重组骨形态发生蛋白-7（rh-BMP-7）修复难治性胫骨骨不连
Int Orthop. 2003;27(5):320-1. doi: 10.1007/s00264-003-0475-4. Epub 2003 Jun 17.
8
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Scand J Surg. 2002;91(2):186-90. doi: 10.1177/145749690209100210.
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OP-1 clinical studies.
J Bone Joint Surg Am. 2001;83-A Suppl 1(Pt 2):S160-1.