Bharali Manuj Kr, Basumatary Rajeev, Rahman Taibur, Dutta Karabi
Department of Zoology, Rajiv Gandhi University, Rono Hill, Itanagar, Arunachal Pradesh, India.
Toxicol Int. 2012 May;19(2):132-7. doi: 10.4103/0971-6580.97206.
Hemolytic anemia and rhabdomyolysis have been often reported to be an adverse effect of drug- and chemical-induced toxicity both in experimental and real-life scenario. para-Phenylenediamine (PPD) is a derivative of para-nitroaniline and has been found as an ingredient of almost all hair dye formulations in varying concentrations from 2% to 4% w/v. Earlier studies have reported that the accidental oral ingestion of PPD in humans can lead to acute renal failure because of rhabdomyolysis. In the present investigation, we have tested the chronic topical application of PPD and its effect on the renal histology of Sprague-Dawley rats. The experiment provides clear evidence that topically applied PPD induces hemolytic anemia as evident from the decrease in the total RBC count, packed cell volume, and hemoglobin content apart from rhabdomyolysis which subsequently causes acute renal failure in rats.
在实验和实际情况中，溶血性贫血和横纹肌溶解症常被报道为药物和化学物质诱导毒性的不良反应。对苯二胺（PPD）是对硝基苯胺的衍生物，已被发现几乎存在于所有染发剂配方中，浓度从2%至4%（w/v）不等。早期研究报道，人类意外口服PPD可因横纹肌溶解症导致急性肾衰竭。在本研究中，我们测试了PPD的慢性局部应用及其对Sprague-Dawley大鼠肾脏组织学的影响。实验提供了明确的证据，局部应用PPD会导致溶血性贫血，这从红细胞总数、血细胞比容和血红蛋白含量的下降中明显可见，此外还会导致横纹肌溶解症，进而导致大鼠急性肾衰竭。
