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围手术期癌症化疗在腹膜表面恶性肿瘤患者中的药代动力学。

Pharmacokinetics of the perioperative use of cancer chemotherapy in peritoneal surface malignancy patients.

机构信息

Department of Surgical Oncology, Oost-Limburg Hospital, Schiepse Bos 6, 3600 Genk, Belgium.

出版信息

Gastroenterol Res Pract. 2012;2012:378064. doi: 10.1155/2012/378064. Epub 2012 Jun 13.

DOI:10.1155/2012/378064
PMID:22778722
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3384921/
Abstract

Background. The peritoneal surface is an acknowledged locoregional failure site of abdominal malignancies. Previous treatment attempts with medical therapy alone did not result in long-term survival. During the last two decades, new treatment protocols combining cytoreductive surgery with perioperative intraperitoneal and intravenous cancer chemotherapy have demonstrated very encouraging clinical results. This paper aims to clarify the pharmacologic base underlying these treatment regimens. Materials and Methods. A review of the current pharmacologic data regarding these perioperative chemotherapy protocols was undertaken. Conclusions. There is a clear pharmacokinetic and pharmacodynamic rationale for perioperative intraperitoneal and intravenous cancer chemotherapy in peritoneal surface malignancy patients.

摘要

背景

腹膜表面是腹部恶性肿瘤公认的局部区域复发部位。既往单纯采用药物治疗的尝试并未带来长期生存。在过去的二十年中，结合细胞减灭术和围手术期腹腔内和静脉内化疗的新治疗方案显示出非常令人鼓舞的临床结果。本文旨在阐明这些治疗方案的药理基础。

材料和方法

对这些围手术期化疗方案的当前药理数据进行了回顾。

结论

对于腹膜表面恶性肿瘤患者，围手术期腹腔内和静脉内化疗具有明确的药代动力学和药效学依据。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2abf/3384921/990a102d5f3c/GRP2012-378064.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2abf/3384921/7cb8c44e0cd1/GRP2012-378064.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2abf/3384921/03a488d21f4e/GRP2012-378064.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2abf/3384921/c02a31bd03dd/GRP2012-378064.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2abf/3384921/990a102d5f3c/GRP2012-378064.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2abf/3384921/7cb8c44e0cd1/GRP2012-378064.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2abf/3384921/03a488d21f4e/GRP2012-378064.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2abf/3384921/c02a31bd03dd/GRP2012-378064.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2abf/3384921/990a102d5f3c/GRP2012-378064.004.jpg

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