Seretis Charalampos, Gill Jagjit, Malik Adnan, Elhassan Ali Mohamed, Shariff Umar, Youssef Haney
George Eliot Hospital NHS Trust, Warwickshire, UK.
General Surgery Department, Good Hope Hospital, Heart of England NHS Foundation Trust, Birmingham, UK.
J Clin Med Res. 2020 Dec;12(12):773-779. doi: 10.14740/jocmr4362. Epub 2020 Dec 18.
Preoperative hypoalbuminemia is known to be associated with postoperative morbidity and mortality, as well as with poor survival after gastrointestinal cancer surgery. However, limited data exist regarding the prognostic significance of hypoalbuminemia in patients with peritoneal metastases undergoing cytoreductive surgery, combined with perioperative intraperitoneal chemotherapy. We performed a systematic literature review of the previously published studies addressing the potential association between preoperative albumin levels and overall surgical outcomes after the performance of cytoreductive surgery and perioperative intraperitoneal chemotherapy for peritoneal surface malignancies. Our research yielded a total of nine retrospective studies which met our inclusion criteria, and despite their heterogeneity; and we can conclude that preoperatively low albumin levels are associated with greater likelihood of overall and major morbidity, as well as less favorable oncological outcome after the performance of cytoreductive surgery and perioperative intraperitoneal chemotherapy.
术前低白蛋白血症已知与术后发病率和死亡率相关，也与胃肠道癌手术后的不良生存情况相关。然而，关于接受减瘤手术联合围手术期腹腔内化疗的腹膜转移患者中低白蛋白血症的预后意义，现有数据有限。我们对先前发表的研究进行了系统的文献综述，这些研究探讨了术前白蛋白水平与腹膜表面恶性肿瘤行减瘤手术及围手术期腹腔内化疗后的总体手术结局之间的潜在关联。我们的研究共纳入了9项符合我们纳入标准的回顾性研究，尽管它们存在异质性；但我们可以得出结论，术前低白蛋白水平与总体和主要发病率增加的可能性相关，也与减瘤手术及围手术期腹腔内化疗后的肿瘤学结局较差相关。
