• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

山荷叶提取物及其衍生植物化学物质对高尿酸血症小鼠的降尿酸作用。

The Hypouricemic Effect of Balanophora laxiflora Extracts and Derived Phytochemicals in Hyperuricemic Mice.

机构信息

Department of Forestry, National Chung Hsing University, Taichung 402, Taiwan.

出版信息

Evid Based Complement Alternat Med. 2012;2012:910152. doi: 10.1155/2012/910152. Epub 2012 Jun 19.

DOI:10.1155/2012/910152
PMID:22778779
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3388452/
Abstract

The objective of this study is to evaluate the lowering of uric acid using Balanophora laxiflora extracts and derived phytochemicals on potassium-oxonate-(PO-) induced hyperuricemia in mice. The results revealed that ethyl acetate (EtOAc) fraction of B. laxiflora extracts exhibited strong xanthine-oxidase-(XOD-) inhibitory activity. In addition, among the 10 subfractions (EA1-10) derived from EtOAc fraction, subfraction 8 (EA8) exhibited the best XOD-inhibitory activity. Four specific phytochemicals, 1-O-(E)-caffeoyl-β-D-glucopyranose (1), 1-O-(E)-p-coumaroyl-β-D-glucopyranose (2), 1,3-di-O-galloyl-4,6-(S)-hexahydroxydiphenoyl-β-D-glucopyranose (3), and 1-O-(E)-caffeoyl-4,6-(S)-hexahydroxydiphenoyl-β-D-glucopyranose (4), were further isolated and identified from this subfraction. Compounds 3 and 4 exhibited the strongest XOD-inhibitory activity compared with other compounds, and both hydrolyzable tannins were determined to be noncompetitive inhibitors according to the Lineweaver-Burk plot. On the other hand, the in vivo hypouricemic effect in hyperuricemic mice was consistent with XOD-inhibitory activity, indicating that B. laxiflora extracts and derived phytochemicals could be potential candidates as new hypouricemic agents.

摘要

本研究旨在评估巴兰诺菲拉提取物及其衍生植物化学物质对氧嗪酸钾（PO-）诱导的小鼠高尿酸血症中尿酸的降低作用。结果表明，巴兰诺菲拉提取物的乙酸乙酯（EtOAc）部分表现出强烈的黄嘌呤氧化酶（XOD-）抑制活性。此外，在 EtOAc 部分衍生的 10 个亚部分（EA1-10）中，亚部分 8（EA8）表现出最好的 XOD 抑制活性。从该亚部分进一步分离和鉴定了四种特定的植物化学物质，1-O-（E）-咖啡酰-β-D-吡喃葡萄糖（1）、1-O-（E）-对香豆酰-β-D-吡喃葡萄糖（2）、1,3-二-O-没食子酰基-4,6-（S）-六羟基二苯甲酰基-β-D-吡喃葡萄糖（3）和 1-O-（E）-咖啡酰基-4,6-（S）-六羟基二苯甲酰基-β-D-吡喃葡萄糖（4）。与其他化合物相比，化合物 3 和 4 表现出最强的 XOD 抑制活性，根据 Lineweaver-Burk 图，两种可水解鞣质均被确定为非竞争性抑制剂。另一方面，在高尿酸血症小鼠中的体内降尿酸作用与 XOD 抑制活性一致，表明巴兰诺菲拉提取物及其衍生植物化学物质可能是新的降尿酸剂的潜在候选物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4caa/3388452/17b0f54ffd69/ECAM2012-910152.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4caa/3388452/88187944f74c/ECAM2012-910152.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4caa/3388452/c2ae8f27c785/ECAM2012-910152.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4caa/3388452/3aad85b2c5f8/ECAM2012-910152.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4caa/3388452/c3aae37c9b63/ECAM2012-910152.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4caa/3388452/17b0f54ffd69/ECAM2012-910152.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4caa/3388452/88187944f74c/ECAM2012-910152.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4caa/3388452/c2ae8f27c785/ECAM2012-910152.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4caa/3388452/3aad85b2c5f8/ECAM2012-910152.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4caa/3388452/c3aae37c9b63/ECAM2012-910152.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4caa/3388452/17b0f54ffd69/ECAM2012-910152.005.jpg

相似文献

1
The Hypouricemic Effect of Balanophora laxiflora Extracts and Derived Phytochemicals in Hyperuricemic Mice.山荷叶提取物及其衍生植物化学物质对高尿酸血症小鼠的降尿酸作用。
Evid Based Complement Alternat Med. 2012;2012:910152. doi: 10.1155/2012/910152. Epub 2012 Jun 19.
2
Phytochemicals from Tradescantia albiflora Kunth Extracts Reduce Serum Uric Acid Levels in Oxonate-induced Rats.紫露草提取物中的植物化学物质可降低氧嗪酸钾诱导的大鼠血清尿酸水平。
Pharmacogn Mag. 2016 May;12(Suppl 2):S223-7. doi: 10.4103/0973-1296.182171. Epub 2016 May 11.
3
Antioxidative phytochemicals from Rhododendron oldhamii Maxim. leaf extracts reduce serum uric acid levels in potassium oxonate-induced hyperuricemic mice.满山红叶片提取物中的抗氧化植物化学物质可降低氧嗪酸钾诱导的高尿酸血症小鼠的血清尿酸水平。
BMC Complement Altern Med. 2015 Dec 1;15:423. doi: 10.1186/s12906-015-0950-7.
4
Evaluation of Xanthine Oxidase Inhibitory Potential and In vivo Hypouricemic Activity of Dimocarpus longan Lour. Extracts.龙眼提取物的黄嘌呤氧化酶抑制潜力及体内降尿酸活性评估
Pharmacogn Mag. 2016 May;12(Suppl 2):S206-12. doi: 10.4103/0973-1296.182176. Epub 2016 May 11.
5
Phytochemicals from Acacia confusa heartwood extracts reduce serum uric acid levels in oxonate-induced mice: their potential use as xanthine oxidase inhibitors.金合欢心材提取物中的植物化学物质可降低黄嘌呤氧化酶诱导的小鼠血清尿酸水平：它们可能作为黄嘌呤氧化酶抑制剂的用途。
J Agric Food Chem. 2010 Sep 22;58(18):9936-41. doi: 10.1021/jf102689k.
6
Isolation and Purification of Galloyl, Caffeoyl, and Hexahydroxydiphenoyl Esters of Glucoses from by High-Speed Countercurrent Chromatography and Their Antioxidant Activities In Vitro.采用高速逆流色谱法从 中分离纯化没食子酰基、咖啡酰基和六羟二苯甲酰基葡萄糖酯及其体外抗氧化活性。
Molecules. 2018 Aug 14;23(8):2027. doi: 10.3390/molecules23082027.
7
Evaluation of the Antihyperuricemic Activity of Phytochemicals from Davallia formosana by Enzyme Assay and Hyperuricemic Mice Model.评价凤尾蕨科植物粗茎鳞毛蕨中化学成分的降尿酸活性。
Evid Based Complement Alternat Med. 2014;2014:873607. doi: 10.1155/2014/873607. Epub 2014 May 4.
8
Xanthine oxidase inhibitory activity and hypouricemic effect of aspalathin from unfermented rooibos.没食子酰基奎尼酸抑制黄嘌呤氧化酶活性和降低血尿酸的作用。
J Food Sci. 2013 Dec;78(12):H1935-9. doi: 10.1111/1750-3841.12304. Epub 2013 Nov 21.
9
Galloyl and hexahydroxydiphenoyl esters of phenylpropanoid glucosides, phenylpropanoids and phenylpropanoid glucosides from rhizome of Balanophora fungosa.来自蛇菰根茎的苯丙素苷、苯丙素和苯丙素苷的没食子酰基和六羟基二苯甲酰基酯。
Chem Pharm Bull (Tokyo). 2009 Dec;57(12):1352-5. doi: 10.1248/cpb.57.1352.
10
Effects of ChondroT on potassium Oxonate-induced Hyperuricemic mice: downregulation of xanthine oxidase and urate transporter 1.软骨素对氧嗪酸钾诱导的高尿酸血症小鼠的影响：下调黄嘌呤氧化酶和尿酸转运蛋白 1。
BMC Complement Altern Med. 2019 Jan 8;19(1):10. doi: 10.1186/s12906-018-2415-2.

引用本文的文献

1
Comparative pharmacognosy and secondary metabolite analysis of Balanophorae herbs from different sources.不同来源的蛇菰科药用植物的比较生药学和次生代谢产物分析。
Hereditas. 2024 Jun 21;161(1):19. doi: 10.1186/s41065-024-00323-1.
2
Anti-inflammatory effect of a triterpenoid from : results of bioactivity-guided isolation.来自[具体来源未给出]的三萜类化合物的抗炎作用：生物活性导向分离的结果
Heliyon. 2022 Mar 5;8(3):e09070. doi: 10.1016/j.heliyon.2022.e09070. eCollection 2022 Mar.
3
The Efficacy and Mechanism of Chinese Herbal Medicines in Lowering Serum Uric Acid Levels: A Systematic Review.

本文引用的文献

1
New advances in the treatment of gout: review of pegloticase.痛风治疗的新进展：聚乙二醇尿酸酶的综述。
Ther Clin Risk Manag. 2010 Oct 27;6:543-50. doi: 10.2147/TCRM.S6043.
2
Gout and its comorbidities.痛风及其合并症。
Bull NYU Hosp Jt Dis. 2010;68(3):199-203.
3
Tetrahydroamentoflavone (THA) from Semecarpus anacardium as a potent inhibitor of xanthine oxidase.没食子酸四氢诃子次酸（THA）抑制黄嘌呤氧化酶的作用及其构效关系研究
中药降低血清尿酸水平的疗效及机制：一项系统评价
Front Pharmacol. 2021 Jan 25;11:578318. doi: 10.3389/fphar.2020.578318. eCollection 2020.
4
Caffeoylquinic acid derivatives rich extract from Gnaphalium pensylvanicum willd. Ameliorates hyperuricemia and acute gouty arthritis in animal model.来自宾夕法尼亚鼠麴草的富含咖啡酰奎尼酸衍生物的提取物可改善动物模型中的高尿酸血症和急性痛风性关节炎。
BMC Complement Altern Med. 2017 Jun 17;17(1):320. doi: 10.1186/s12906-017-1834-9.
5
Phytochemicals from Tradescantia albiflora Kunth Extracts Reduce Serum Uric Acid Levels in Oxonate-induced Rats.紫露草提取物中的植物化学物质可降低氧嗪酸钾诱导的大鼠血清尿酸水平。
Pharmacogn Mag. 2016 May;12(Suppl 2):S223-7. doi: 10.4103/0973-1296.182171. Epub 2016 May 11.
6
Evaluation of the Antihyperuricemic Activity of Phytochemicals from Davallia formosana by Enzyme Assay and Hyperuricemic Mice Model.评价凤尾蕨科植物粗茎鳞毛蕨中化学成分的降尿酸活性。
Evid Based Complement Alternat Med. 2014;2014:873607. doi: 10.1155/2014/873607. Epub 2014 May 4.
J Ethnopharmacol. 2011 Feb 16;133(3):1117-20. doi: 10.1016/j.jep.2010.10.027. Epub 2010 Oct 20.
4
Phytochemicals from Acacia confusa heartwood extracts reduce serum uric acid levels in oxonate-induced mice: their potential use as xanthine oxidase inhibitors.金合欢心材提取物中的植物化学物质可降低黄嘌呤氧化酶诱导的小鼠血清尿酸水平：它们可能作为黄嘌呤氧化酶抑制剂的用途。
J Agric Food Chem. 2010 Sep 22;58(18):9936-41. doi: 10.1021/jf102689k.
5
Xanthine oxidase inhibitory properties of Czech medicinal plants.捷克药用植物的黄嘌呤氧化酶抑制特性。
J Ethnopharmacol. 2010 Nov 11;132(2):461-5. doi: 10.1016/j.jep.2010.08.044. Epub 2010 Aug 26.
6
Uric acid transport and disease.尿酸转运与疾病。
J Clin Invest. 2010 Jun;120(6):1791-9. doi: 10.1172/JCI42344. Epub 2010 Jun 1.
7
Papuabalanols A and B, new tannins from Balanophora papuana.巴布亚巴兰诺醇A和B，来自巴布亚蛇菰的新单宁。
Chem Pharm Bull (Tokyo). 2010 May;58(5):738-41. doi: 10.1248/cpb.58.738.
8
Inhibition of xanthine oxidase by Acacia confusa extracts and their phytochemicals.金合欢提取物及其植物化学物质对黄嘌呤氧化酶的抑制作用。
J Agric Food Chem. 2010 Jan 27;58(2):781-6. doi: 10.1021/jf901498q.
9
Theoretical study of the mechanism of inhibition of xanthine oxidase by flavonoids and gallic acid derivatives.黄酮类和没食子酸衍生物抑制黄嘌呤氧化酶机制的理论研究。
J Phys Chem B. 2010 Jan 21;114(2):921-8. doi: 10.1021/jp9041809.
10
Lonicera hypoglauca inhibits xanthine oxidase and reduces serum uric acid in mice.淡红忍冬抑制小鼠黄嘌呤氧化酶并降低血清尿酸。
Planta Med. 2009 Mar;75(4):302-6. doi: 10.1055/s-0029-1185300. Epub 2009 Jan 30.