Bagherani Nooshin
Nooshin Bagherani's Office, 2nd Floor, Taha Physicians' Building, 40-Meter Street, Khoramshahr, Khuzestan Province, Iran.
ISRN Dermatol. 2012;2012:405268. doi: 10.5402/2012/405268. Epub 2012 Jun 19.
Zinc-α2-glycoprotein (ZAG) is a recently identified adipokine, assigned to the chromosome 7q22.1. It is a multidisciplinary protein, which is secreted in various body fluids. The ZAG plays roles in lipolysis, regulation of metabolism, cell proliferation and differentiation, regulation of melanin synthesis, cell adhesion, immunoregulation, and so forth. Vitiligo is the most common depigmenting skin disorder, characterized by acquired, progressive, and circumscribed amelanosis of the skin and hair. It commonly begins in childhood or young adulthood. The pathogenesis of this disorder is uncertain, but it appears to be dependent on the interaction of genetic, immunological, and neurological factors. For the first time, we pointed the probable association between ZAG and vitiligo. Herein, I have described this association in different views. By confirming this association, a surprising progression will occur in the treatment of this prevalent debilitating disease.
锌-α2-糖蛋白（ZAG）是一种最近发现的脂肪因子，定位于7号染色体q22.1区域。它是一种多学科相关的蛋白质，在多种体液中分泌。ZAG在脂肪分解、代谢调节、细胞增殖与分化、黑色素合成调节、细胞黏附、免疫调节等方面发挥作用。白癜风是最常见的色素脱失性皮肤病，其特征为皮肤和毛发出现后天性、进行性和局限性色素脱失。它通常始于儿童期或青年期。这种疾病的发病机制尚不确定，但似乎取决于遗传、免疫和神经因素的相互作用。我们首次指出了ZAG与白癜风之间可能存在的关联。在此，我从不同角度描述了这种关联。通过证实这种关联，在治疗这种普遍存在的使人衰弱的疾病方面将出现惊人的进展。
