Kakar A, Kakar K, Sreenivasan P K, DeVizio W, Kohli R
Global Health Research Group, New Delhi, India.
J Clin Dent. 2012;23(2):40-7.
This clinical study was designed to compare dentin hypersensitivity relief among subjects who brushed their teeth with a new toothpaste containing 8.0% arginine, calcium carbonate, and 1000 ppm fluoride as sodium monofluorophosphate (MFP) to subjects who brushed with a commercially available dentifrice containing 2% potassium ion as potassium nitrate over an eight-week period.
Adult male and female subjects from the New Delhi, India area were required to present two teeth that exhibited dentin hypersensitivity, both to tactile stimulation using the Yeaple Probe and to air blast stimulation delivered by a standard dental unit syringe. After an examination of the oral soft and hard tissues, qualifying subjects were randomly assigned one of the study dentifrices and a soft-bristled toothbrush, and were instructed to brush their teeth for one minute, twice daily (morning and evening), using only the toothbrush and dentifrice provided. No other oral hygiene practices were permitted over the course of the study. After two, four, and eight weeks of product use, subjects returned to the dental clinic for follow-up examinations of tactile and air blast sensitivity of the baseline-designated hypersensitive teeth. Examinations of the oral soft and hard tissues were also performed at these follow-up visits.
Subjects who brushed with the new dentifrice containing 8.0% arginine, calcium carbonate, and 1000 ppm MFP exhibited statistically significant reductions (p < 0.05) in dentin hypersensitivity in response to tactile (36.2%, 33.1%, and 29.7%) and air blast (16.4%, 31.1%, 58.8%) stimuli when compared to the subjects who brushed with the 2% potassium ion as potassium nitrate dentifrice after two, four, and eight weeks, respectively.
The use ofa new dentifrice containing 8.0% arginine, calcium carbonate, and 1000 ppm MFP provides greater efficacy in reducing dentin hypersensitivity when compared to a dentifrice containing 2% potassium ion, as potassium nitrate, after two, four, and eight weeks of product use.
本临床研究旨在比较使用含8.0%精氨酸、碳酸钙和1000 ppm氟（以单氟磷酸钠形式存在）的新型牙膏刷牙的受试者与使用含2%钾离子（以硝酸钾形式存在）的市售牙膏刷牙的受试者在八周时间内牙本质过敏缓解情况。
来自印度新德里地区的成年男性和女性受试者需提供两颗表现出牙本质过敏的牙齿，对使用耶普尔探针进行的触觉刺激以及标准牙科治疗台注射器进行的气喷刺激均有反应。在对口腔软硬组织进行检查后，符合条件的受试者被随机分配一种研究牙膏和一把软毛牙刷，并被指示每天早晚仅使用提供的牙刷和牙膏刷牙一分钟。在研究过程中不允许进行其他口腔卫生措施。在使用产品两周、四周和八周后，受试者返回牙科诊所对基线指定的过敏牙齿进行触觉和气喷敏感性的随访检查。在这些随访就诊时也对口腔软硬组织进行检查。
与使用含2%钾离子（以硝酸钾形式存在）牙膏刷牙的受试者相比，使用含8.0%精氨酸、碳酸钙和1000 ppm单氟磷酸钠的新型牙膏刷牙的受试者在使用产品两周、四周和八周后，对触觉（分别为36.2%、33.1%和29.7%）和气喷（分别为16.4%、31.1%、58.8%）刺激的牙本质过敏有统计学显著降低（p < 0.05）。
在产品使用两周、四周和八周后，与含2%钾离子（以硝酸钾形式存在）的牙膏相比，使用含8.0%精氨酸、碳酸钙和1000 ppm单氟磷酸钠的新型牙膏在降低牙本质过敏方面具有更高的疗效。
