Department of Restorative and Cosmetic Dentistry, Mashhad Dental School, Mashhad University of Medical Sciences, Mashhad, Iran.
Dental Materials Research Center, School of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran.
BMC Oral Health. 2024 Apr 29;24(1):507. doi: 10.1186/s12903-024-04298-3.
Dentin hypersensitivity, often occurring after dental treatments or from erosive lesions, is a prevalent patient complaint. This study introduces a paste combining 8% L-arginine, calcium carbonate, and potassium nitrate to evaluate its impact on dentinal tubules occlusion, dentin permeability, and tooth sensitivity.
Dentin surfaces from 24 third molars (thickness: 2 mm) were divided into two groups of 12. One received the experimental paste, while the other received a placebo without desensitizer. Permeability and sealing ability were assessed through scanning electron microscopy (SEM) and dentin permeability measurement. The pastes' effects on hypersensitivity were then examined in a triple-blind, randomized parallel-armed clinical trial with 16 eligible patients. Sensitivity to cold, touch, and spontaneous stimuli was recorded using the VAS scale at various intervals post-treatment. Statistical analysis was conducted using Shapiro-Wilk, Mann-Whitney U, Friedman, and Wilcoxon tests (α = 0.05).
The permeability test demonstrated a significant reduction in dentin permeability in the experimental group (P = 0.002) compared to the control (P = 0.178). SEM images revealed most dentinal tubules in the intervention samples to be occluded. Clinically, both groups showed a significant decrease in the three types of evaluated sensitivity throughout the study. However, no significant difference in sensitivities between the two groups was observed, with the exception of cold sensitivity at three months post-treatment (P = 0.054).
The innovative desensitizing paste featuring 8% L-arginine, calcium carbonate, and potassium nitrate effectively occluded dentinal tubules and reduced dentin permeability. It mitigated immediate and prolonged dentin hypersensitivity to various stimuli, supporting its potential role in managing dentin hypersensitivity.
http://irct.ir : IRCT20220829055822N1, September 9th, 2022.
牙本质敏感症常发生于牙体治疗后或因侵蚀性病变，是一种常见的患者主诉。本研究介绍了一种含有 8%L-精氨酸、碳酸钙和硝酸钾的糊剂，用以评估其对牙本质小管封闭、牙本质渗透性和牙齿敏感性的影响。
从 24 颗第三磨牙（厚度：2mm）中分出两组各 12 颗。一组接受实验糊剂，另一组接受不含脱敏剂的安慰剂。通过扫描电子显微镜（SEM）和牙本质渗透性测量评估渗透性和封闭能力。然后，在一项具有 16 名合格患者的三盲、随机平行臂临床试验中，检查糊剂对过敏的影响。在治疗后不同时间间隔，使用视觉模拟量表（VAS）记录对冷、触和自发刺激的敏感性。使用 Shapiro-Wilk、Mann-Whitney U、Friedman 和 Wilcoxon 检验（α=0.05）进行统计分析。
渗透性测试表明，实验组牙本质渗透性显著降低（P=0.002），而对照组则无显著变化（P=0.178）。SEM 图像显示干预样本中大多数牙本质小管被封闭。临床研究中，两组在整个研究过程中三种评估敏感性均显著降低。然而，两组之间的敏感性差异无统计学意义，除了治疗后三个月的冷敏感性（P=0.054）。
这款创新性脱敏糊剂含有 8%L-精氨酸、碳酸钙和硝酸钾，可有效封闭牙本质小管并降低牙本质渗透性。它减轻了各种刺激引起的即刻和长期牙本质敏感，支持其在管理牙本质敏感中的潜在作用。
http://irct.ir：IRCT20220829055822N1，2022 年 9 月 9 日。
