Colucci Vivian, Messias Danielle Cristine Furtado, Serra Mônica Campos, Corona Silmara Aparecida Milori, Turssi Cecilia Pedroso
Department of Operative Dentistry, Ribeirão Preto School of Dentistry, Universit of São Paulo, Ribeirão Preto, São Paulo, Brazil.
Am J Dent. 2012 Apr;25(2):114-7.
To evaluate the effect of a 1.23% acidulated phosphate fluoride (APF) gel combined with CO2 laser in protecting carious root dentin against further cariogenic challenges.
After a 7-day lead-in period, 12 volunteers wore an intraoral palatal device containing four carious root dentin slabs, treated with APF and APF+CO2 or placebo and placebo+CO2. After a 14-day wash-out period, volunteers were crossed-over to the other treatment arm. During both intraoral phases, specimens were submitted to cariogenic challenges and then evaluated for cross-sectional Knoop microhardness.
Two-way ANOVA demonstrated that there was significant effect for both main factors: CO2 laser irradiation (P < 0.0001) and gel treatment (P < 0.0001), and that there was no interaction between them (P = 0.4706). Protection of carious root dentin against further cariogenic challenges may be provided by APF fluoride gel and CO2 laser, but no additive benefit was found by combining such strategies.
评估1.23% 酸化磷酸氟（APF）凝胶联合二氧化碳激光在保护龋坏根面牙本质免受进一步致龋挑战方面的效果。
在为期7天的导入期后，12名志愿者佩戴一种口内腭部装置，该装置包含四块龋坏根面牙本质块，分别用APF、APF + 二氧化碳激光、安慰剂或安慰剂 + 二氧化碳激光进行处理。在为期14天的洗脱期后，志愿者交叉至另一个治疗组。在两个口内阶段，标本均接受致龋挑战，然后评估其横断面努氏显微硬度。
双向方差分析表明，两个主要因素均有显著影响：二氧化碳激光照射（P < 0.0001）和凝胶处理（P < 0.0001），且二者之间无交互作用（P = 0.4706）。APF氟凝胶和二氧化碳激光可保护龋坏根面牙本质免受进一步致龋挑战，但联合使用这些策略未发现额外益处。
