Dzielska-Olczak Małgorzata, Nowak Jerzy Z
Uniwersytet Medyczny w Łodzi, Zakład Farmakologii Katedry Farmakologii i Farmakologii Klinicznej.
Pol Merkur Lekarski. 2012 May;32(191):329-34.
Osteoarthritis (ostheoarthrosis, OA) is characterized by progressive destruction of articular cartilage, remodeling of the periarticular bone and inflammation of the synovial membrane. In patients occur joints pain, impaired joints motion and disability. The results of many studies indicate an inflammation as foundation of this disease. The management of OA include a combination of pharmacological treatments and nonpharmacological interventions. Pharmacological treatments include used paracetamol, nonsteroidal anti-inflammatory drugs (NSAIDs) and chondroprotectives (glucosamine, chondroitin sulfate and so on). NSAIDs long-term use associated with serious adverse effects. OA symptoms are effectively reduced by nutrients such omega 3 and omega 6 fatty acids (PUFAs as EPA, DHA), which decrease the need for non-steroidal drugs and may less adverse events. They exerts, particularly EPA, anti-inflammatory effect, inhibit catabolic processes, stimulate the anabolic process in the cartilage in the joint. Many different evidence validate that omega 3 alleviate the progression of osteoarthritis and have exciting therapeutic potential for preventing cartilage degradation associated with chronic inflammatory in joints.
骨关节炎（骨关节病，OA）的特征是关节软骨进行性破坏、关节周围骨重塑和滑膜炎症。患者会出现关节疼痛、关节活动受限和残疾。许多研究结果表明炎症是这种疾病的基础。OA的治疗包括药物治疗和非药物干预相结合。药物治疗包括使用对乙酰氨基酚、非甾体抗炎药（NSAIDs）和软骨保护剂（氨基葡萄糖、硫酸软骨素等）。长期使用NSAIDs会带来严重的不良反应。ω-3和ω-6脂肪酸（如EPA、DHA等多不饱和脂肪酸，PUFAs）等营养物质可有效减轻OA症状，减少对非甾体药物的需求，并可能减少不良事件。它们，尤其是EPA，具有抗炎作用，抑制分解代谢过程，刺激关节软骨中的合成代谢过程。许多不同的证据证实，ω-3可缓解骨关节炎的进展，对于预防与关节慢性炎症相关的软骨降解具有令人兴奋的治疗潜力。
