Zhang Hongru, Qi Liwei, Shen Qingshan, Wang Ruiqi, Guo Yujie, Zhang Chunhui, Richel Aurore
Key Laboratory of Agro-Products Processing, Ministry of Agriculture and Rural Affairs, Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences, Beijing, China.
Laboratory of Biomass and Green Technologies, University of Liege-Gembloux Agro-Bio Tech, Gembloux, Belgium.
Front Nutr. 2022 Mar 30;9:843360. doi: 10.3389/fnut.2022.843360. eCollection 2022.
This study was designed to explore osteoarthritis (OA) treatment from bioactive compounds of chicken cartilage food supplements. The OA rat model induced by sodium iodoacetate was used to evaluate the treatment effect . In this study, we used animal experiments to show that oral chondroitin sulfate (CS), cartilage powder, and type II collagen peptides could increase the athletic ability of rats and reduce inflammatory cytokine levels in serum or synovial fluid, including prostaglandin E, tumor necrosis factor-α, interleukin (IL) 1β, IL-6, and IL-17. CS displayed the best treatment effect against OA. The morphological structure of articular cartilage indicated that CS could significantly improve cartilage tissue morphology and reduce OA score. Oral CS slowed down the development of OA by modulating gut microbiota. These results provided a useful scientific basis for the high-value utilization of chicken cartilage.
本研究旨在从鸡软骨食品补充剂的生物活性化合物中探索骨关节炎（OA）的治疗方法。使用碘乙酸钠诱导的OA大鼠模型来评估治疗效果。在本研究中，我们通过动物实验表明，口服硫酸软骨素（CS）、软骨粉和II型胶原蛋白肽可以提高大鼠的运动能力，并降低血清或滑液中的炎症细胞因子水平，包括前列腺素E、肿瘤坏死因子-α、白细胞介素（IL）1β、IL-6和IL-17。CS对OA显示出最佳治疗效果。关节软骨的形态结构表明，CS可以显著改善软骨组织形态并降低OA评分。口服CS通过调节肠道微生物群减缓了OA的发展。这些结果为鸡软骨的高值利用提供了有用的科学依据。
