Graduate School of Pharmaceutical Sciences, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
J Am Chem Soc. 2012 Jul 25;134(29):11995-7. doi: 10.1021/ja305856q. Epub 2012 Jul 13.
A first asymmetric total synthesis of (-)-isoschizogamine has been accomplished. Our synthesis features the facile construction of the carbon framework of the natural product through a Wagner-Meerwein rearrangement, a tandem metathesis, a stereoselective rhodium-mediated 1,4-addition of an arylboronic acid, and a ring-closing metathesis via a hemiaminal ether.
已完成（-）-异裂石蒜碱的首次不对称全合成。我们的合成方法通过 Wagner-Meerwein 重排、串联复分解、立体选择性铑介导的芳基硼酸 1,4-加成反应和通过半缩醛醚的闭环复分解反应，轻松构建了天然产物的碳骨架。
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