Department of Chemistry and Biochemistry, The University of Texas, Austin, Texas 78712, USA.
Org Lett. 2010 Aug 20;12(16):3622-5. doi: 10.1021/ol101356u.
A concise synthesis of (+/-)-pseudotabersonine from commercially available 1-(phenylsulfonyl)-3-indolecarboxaldehyde has been accomplished. This synthesis features the convergent assembly of a key intermediate via a stepwise variant of a Mannich-type multicomponent coupling process, a double ring-closing metathesis, and a one-pot deprotection/cyclization reaction.
已完成从商业可得的 1-(苯磺酰基)-3-吲哚甲醛简洁合成(±)-伪骆驼蓬碱。该合成通过 Mannich 型多组分偶联过程的分步变体、双环 closing metathesis 和一锅脱保护/环化反应,实现了关键中间体的会聚组装。