Kennedy D A, Woodland C, Koren G
The Motherisk Program, Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children, Canada.
J Obstet Gynaecol. 2012 Aug;32(6):512-7. doi: 10.3109/01443615.2012.693987.
The association between lead and hypertension in adults was first identified in the early 1980's and it has since been proposed that lead may also have a role in gestational hypertension (GH). This systematic review investigates whether lead may be associated with the development of GH or pre-eclampsia. MEDLINE, Embase and Web of Science were searched from inception to August 2011, using the terms: blood lead levels, pregnancy, pregnancy induced hypertension, gestational hypertension and pre-eclampsia. Nine papers were found. Positive associations between lead and GH or pre-eclampsia were found in six studies. The development of GH or pre-eclampsia may serve as a signal to assess blood lead concentrations in pregnant women, as even low lead concentrations have been shown to negatively impact the neurodevelopment and cognitive abilities of children. Adequate calcium intake throughout the pregnancy and lactation period may assist with reducing lead exposure levels.
成人铅与高血压之间的关联最早于20世纪80年代初被发现，此后有人提出铅可能在妊娠期高血压（GH）中也起作用。本系统评价调查铅是否可能与GH或子痫前期的发生有关。从创刊至2011年8月检索了MEDLINE、Embase和科学引文索引数据库，检索词为：血铅水平、妊娠、妊娠高血压、妊娠期高血压和子痫前期。共找到9篇论文。六项研究发现铅与GH或子痫前期之间存在正相关。GH或子痫前期的发生可能作为评估孕妇血铅浓度的一个信号，因为即使是低铅浓度也已被证明会对儿童的神经发育和认知能力产生负面影响。在整个妊娠和哺乳期摄入足够的钙可能有助于降低铅暴露水平。
