Salem H, El-Mazny A
Department of Urosurgery, Faculty of Medicine, Cairo University, Egypt.
J Obstet Gynaecol. 2012 Aug;32(6):590-3. doi: 10.3109/01443615.2012.693980.
The pathological analysis of cystectomy specimens from 360 female patients who underwent radical cystectomy for bladder cancer was retrospectively reported. The uterus was not available in 29 specimens, while one ovary was absent in 18 specimens and the two ovaries were absent in 20 specimens. Uterine involvement was observed in one case of transitional cell carcinoma, and benign uterine pathology was detected in 37 cases. All patients had normal ovaries, while the vagina was involved in 13 cases. A total of 12% of the patients had urethral involvement. None of the 29 patients, in whom the internal genitalia were totally or partially preserved, had late ovarian, vaginal or uterine recurrence at the last follow-up. Thus, the preservation of female internal genitalia in young patients undergoing radical cystectomy should be considered under strict criteria (low-grade, low-stage tumours away from the bladder neck). This will improve the quality-of-life (QoL) and the functional outcome without compromising cancer control.
回顾性报告了360例因膀胱癌接受根治性膀胱切除术的女性患者膀胱切除标本的病理分析结果。29份标本中未发现子宫，18份标本中一侧卵巢缺失，20份标本中双侧卵巢缺失。1例移行细胞癌患者观察到子宫受累，37例患者检测到良性子宫病变。所有患者卵巢均正常，13例患者阴道受累。共有12%的患者出现尿道受累。在29例保留了全部或部分内生殖器的患者中，末次随访时均无卵巢、阴道或子宫晚期复发。因此，对于接受根治性膀胱切除术的年轻患者，应在严格标准（低级别、低分期肿瘤且远离膀胱颈）下考虑保留女性内生殖器。这将在不影响癌症控制的情况下改善生活质量（QoL）和功能结局。
