[雄性Wistar大鼠某些身体功能的年龄依赖性变化]
[Age-dependent changes of some body functions in male Wistar rats].
作者信息
Zhan H, Liu C G, Zhou J H
机构信息
Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing.
出版信息
Sheng Li Xue Bao. 1990 Oct;42(5):503-8.
It was shown in this experiment that many systematic functions in male Wistar rats gradually declined during aging. Compared with young rats, thymus weight or the weight index decreased significantly in the 13- and 24-month rats (P less than 0.001). Age-dependent decreases of proliferation rate of splenic T lymphocyte, plasma testosterone (T) and estradiol (E2) level, concentration of cytochrome P-450 and activity of mixed functional oxidase (MFO) in liver microsomes were also observed.
本实验表明，雄性Wistar大鼠的许多系统功能在衰老过程中逐渐衰退。与年轻大鼠相比，13个月和24个月大鼠的胸腺重量或重量指数显著降低（P<0.001）。还观察到脾脏T淋巴细胞增殖率、血浆睾酮（T）和雌二醇（E2）水平、细胞色素P-450浓度以及肝脏微粒体中混合功能氧化酶（MFO）活性随年龄增长而下降。
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