Fernandez V, Kriz A, Videla L A
Departamento de Ciencias Biológicas, Facultad de Medicina, Universidad de Chile, Santiago.
Cell Biochem Funct. 1988 Jan;6(1):7-12. doi: 10.1002/cbf.290060103.
The study of the influence of the age of the animals (13 to 53 weeks) on the rate of ethanol metabolism in vivo and the total activity of liver alcohol dehydrogenase and microsomal ethanol oxidizing system showed a progressive decline with age. These effects were observed concomitantly with a diminution in the content of cytochrome P-450 and microsomal functions related to oxidative and free-radical mediated reactions, namely, NADPH oxidase activity, NADPH-dependent oxygen uptake and NADPH-or t-butyl hydroperoxide-induced chemiluminescence. It is concluded that ageing is accompanied by a diminution in the total oxidative activity of the liver tissue, which would explain the depression in basal and ethanol-induced lipid peroxidation found in the oldest group of rats studied.
对动物年龄（13至53周）对体内乙醇代谢速率以及肝脏乙醇脱氢酶和微粒体乙醇氧化系统总活性的影响的研究表明，随着年龄增长，这些指标呈逐渐下降趋势。这些影响与细胞色素P - 450含量的减少以及与氧化和自由基介导反应相关的微粒体功能的降低同时出现，即NADPH氧化酶活性、NADPH依赖性氧摄取以及NADPH或叔丁基过氧化氢诱导的化学发光。得出的结论是，衰老伴随着肝脏组织总氧化活性的降低，这可以解释在研究的最老龄大鼠组中发现的基础和乙醇诱导的脂质过氧化的降低。
