Laboratory of Molecular Toxicology, State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing, PR China.
Biomarkers. 2012 Sep;17(6):566-74. doi: 10.3109/1354750X.2012.704527. Epub 2012 Jul 10.
Carbamate insecticide propoxur is widely used in agriculture and public health programs. To prevent adverse health effects arising from exposure to this insecticide, sensitive methods for detection of early stage organismal changes are necessary. We present here an integrative metabonomic approach to investigate toxic effects of pesticide in experimental animals. Results showed that propoxur even at low dose levels can induce oxidative stress, impair liver function, enhance ketogenesis and fatty acid β-oxidation, and increase glycolysis, which contribute to the hepatotoxocity. These findings highlight the applicability of (1)H NMR spectroscopy and multivariate statistics in elucidating the toxic effects of propoxur.
氨基甲酸酯类杀虫剂残杀威在农业和公共卫生项目中被广泛使用。为了防止因接触这种杀虫剂而产生不良健康影响，有必要采用敏感的方法来检测早期的机体变化。我们在此提出一种综合的代谢组学方法来研究农药对实验动物的毒性作用。结果表明，即使在低剂量水平下，残杀威也能诱导氧化应激，损害肝功能，增强酮体生成和脂肪酸β氧化，并增加糖酵解，这有助于肝毒性。这些发现突出了（1）H NMR 光谱和多变量统计在阐明残杀威毒性作用方面的适用性。
