Department of General Medicine, John Hunter Hospital, Newcastle, NSW, Australia.
Australas J Dermatol. 2013 Feb;54(1):61-3. doi: 10.1111/j.1440-0960.2012.00924.x. Epub 2012 Jul 11.
Infliximab is a high-affinity recombinant chimeric immunoglobulin-1 monoclonal antibody directed against tumour necrosis factor-alpha. It is used to treat a range of inflammatory disorders including psoriatic joint and skin changes. Acute interstitial lung disease is a rare but potentially fatal complication of therapy. We report the case of a 67-year-old man with severe psoriasis who presented with acute alveolitis shortly after his third infusion of infliximab. The infliximab was discontinued and investigations did not reveal an infective cause. His respiratory signs and symptoms improved quickly with corticosteroid therapy. Clinicians should be aware of this uncommon but potentially serious complication.
英夫利昔单抗是一种高亲和力的重组嵌合免疫球蛋白 G1 单克隆抗体，靶向肿瘤坏死因子-α。它被用于治疗多种炎症性疾病，包括银屑病性关节炎和皮肤变化。急性间质性肺病是治疗的罕见但潜在致命的并发症。我们报告了一例 67 岁男性，患有严重银屑病，在第三次输注英夫利昔单抗后不久出现急性肺泡炎。英夫利昔单抗被停用，且检查未发现感染原因。他的呼吸症状和体征在皮质类固醇治疗后迅速改善。临床医生应意识到这种不常见但潜在严重的并发症。
