Organic Chemistry Laboratory, University of Bayreuth, Universitaetsstrasse 30, 95440 Bayreuth, Germany.
Curr Med Chem. 2012;19(23):3949-56. doi: 10.2174/092986712802002482.
Breast cancer is still the leading cause of cancer deaths among women worldwide, and new therapies to treat this dangerous disease are desperately needed. The serendipitously found anticancer drug cisplatin and its second-generation congener carboplatin appear to be promising drug systems for the treatment of breast tumors, in particular of multidrug resistant and highly aggressive triple-negative subtypes. In the wake of these platinum drugs, complexes of the coinage metals copper, silver, and gold were developed that showed enhanced selectivity for breast cancer while causing fewer and weaker side-effects. This review takes stock of the latest developments in the field of coinage metal anticancer drugs with an emphasis on their biological and mechanistic aspects. Pertinent literature is covered up to 2012.
乳腺癌仍然是全世界女性癌症死亡的主要原因，因此迫切需要新的治疗这种危险疾病的疗法。偶然发现的抗癌药物顺铂及其第二代类似物卡铂似乎是治疗乳腺癌，特别是多药耐药和高度侵袭性三阴性亚型的很有前途的药物系统。在这些铂类药物之后，开发了铜、银和金等贱金属的配合物，这些配合物对乳腺癌具有更高的选择性，同时引起的副作用更少且更弱。本文综述了贱金属抗癌药物领域的最新进展，重点介绍了它们的生物学和机制方面。相关文献截止到 2012 年。
