Yoshitomi K, Brown H R, Eustis S
Experimental Pathology Laboratories, Inc. National Institute of Environmental Health Sciences, Research Triangle Park, NC.
Vet Pathol. 1990 Nov;27(6):432-8. doi: 10.1177/030098589902700608.
Fordyce's granules were observed in the gingiva of the upper incisor and molar teeth in F344 rats. The data were based on 734 males and 722 females that were used as control and treated animals in 26-week, 65-week, and 2-year studies by the National Toxicology Program. The incidence of Fordyce's granules was markedly different when comparing sex, age, and site of the lesion. Fordyce's granules were very common in the midsagittal gingiva of the upper incisor in males and increased in incidence with age (34.2, 50, and 56.3% in 26-week, 65-week, and 2-year studies, respectively). The granules of the incisor gingiva were rare in females (0,0, and 2.8% in 26-week, 65-week, and 2-year studies, respectively). Fordyce's granules of the molar gingiva were very rare in both sexes and were found only in 9/734 (1.2%) males and in 3/722 (0.4%) females. Only three unilateral granules of the molar were grossly recognized as focal swelling of the gingiva or a white nodule with a huge cyst in the third upper molar. Histologically, Fordyce's granules were arranged as a collection of sebaceous glands unassociated with hair follicles. In addition, the granules of the molar gingiva were associated with cystically dilated ducts filled with sebum. Ultrastructurally, the sebaceous cells were characterized by varying numbers of cytoplasmic lipid droplets and occasional desmosome and hemidesmosome formation. Fordyce's granules previously reported in rats of other strains were also reviewed and compared with those in F344 rats in regard to incidence, location, and age.
在F344大鼠的上颌切牙和磨牙牙龈中观察到了福代斯颗粒。这些数据基于734只雄性和722只雌性大鼠，它们在国家毒理学计划进行的26周、65周和2年研究中用作对照和受试动物。比较性别、年龄和病变部位时，福代斯颗粒的发生率有显著差异。福代斯颗粒在雄性大鼠上颌切牙的正中矢状牙龈中非常常见，且发生率随年龄增加（在26周、65周和2年研究中分别为34.2%、50%和56.3%）。切牙牙龈的颗粒在雌性大鼠中很少见（在26周、65周和2年研究中分别为0%、0%和2.8%）。磨牙牙龈的福代斯颗粒在两性中都非常罕见，仅在9/734（1.2%）的雄性和3/722（0.4%）的雌性中发现。只有三颗磨牙的单侧颗粒在大体上被识别为牙龈的局灶性肿胀或上颌第三磨牙中带有巨大囊肿的白色结节。组织学上，福代斯颗粒是由不与毛囊相关的皮脂腺聚集而成。此外，磨牙牙龈的颗粒与充满皮脂的囊性扩张导管有关。超微结构上，皮脂腺细胞的特征是含有数量不等的细胞质脂滴，偶尔形成桥粒和半桥粒。还回顾了先前在其他品系大鼠中报道的福代斯颗粒，并在发生率、位置和年龄方面与F344大鼠中的进行了比较。
