Polymers of Ministry of Education, College of Chemistry and Molecular Science, Wuhan University, Wuhan, 430072, PR China.
Chem Commun (Camb). 2012 Aug 21;48(65):8129-31. doi: 10.1039/c2cc34225a. Epub 2012 Jul 10.
With the decrease in pH value, the 'nano-flower' exhibited a half-open state to expose the target ligands on the surface under tumor acidic conditions and fully bloomed to release Dox under endosomal acidic conditions.
随着 pH 值的降低，“纳米花”在肿瘤酸性条件下呈现半开放状态，暴露出表面的靶配体，并在内体酸性条件下完全展开释放阿霉素。
