皮下脂肪细胞可能会变成成骨细胞。
Subcutaneous adipocytes may become osteoblasts.
作者信息
Ciuffi Simone, Fabbri Sergio, Zonefrati Roberto, Galli Gianna, Tanini Annalisa, Brandi Maria Luisa
机构信息
Department of Internal Medicine, University of Florence, Florence, Italy.
出版信息
Clin Cases Miner Bone Metab. 2012 Jan;9(1):28-30. Epub 2012 May 29.
Commonly, mesenchymal stem cells derived from bone marrow (BMSCs) are mainly utilized in regenerative medicine field. BMSCs are able to differentiate into several lineages, showing immunosuppressive properties, and they are genetically stable in long-term cultures. In the last years, another mesenchymal stem cells population, obtained from adipose tissue, defined adipose-derived stem/stromal cells (ASCs), it is under assessment of scientific research, as alternative to BMSCs. In fact, ASCs show similar capacity to BMSCs, but unlike BMSCs can be harvested more easily with an higher yield and with less invasive manipulation. In this review the abilities of ASCs to differentiate in osteoblasts cells are shown.
通常，源自骨髓的间充质干细胞（BMSCs）主要应用于再生医学领域。BMSCs能够分化为多种细胞谱系，具有免疫抑制特性，并且在长期培养中基因稳定。近年来，另一种从脂肪组织中获得的间充质干细胞群体，即脂肪来源的干细胞/基质细胞（ASCs），作为BMSCs的替代物正在接受科学研究评估。事实上，ASCs表现出与BMSCs相似的能力，但与BMSCs不同的是，ASCs更容易获取，产量更高，操作侵入性更小。在这篇综述中展示了ASCs分化为成骨细胞的能力。
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