Rossini Maurizio, Caimmi Cristian, Giannini Sandro, Sella Stefania, Mattarei Alberto, Lovato Roberto, Piazza Ilaria, Fassio Angelo, Persi Pierluigi, Benetollo Pier Paolo, Adami Silvano
Osteoporosis Centers, Veneto Region, Italy, Integrated University Hospital of Verona, Verona, Italy.
Clin Cases Miner Bone Metab. 2012 Jan;9(1):45-9. Epub 2012 May 29.
to assess the prevalence of the most relevant environmental and individual risk factors in subjects with a recent hip fracture was the aim of this observational study promoted by the Health Authorities of the Regione Veneto (Italy).
patients aged > 60 years of both genders with a recent hip fracture not associated with malignancies, were administered questionnaires on dietary habits, sun exposure, disability score. A complete family, pharmacological and pathology history was collected together with previous falls, details of the fracture index, anthropometric data. In a subgroup of patients blood was taken for the measurements of serum 25 hydroxy-vitamin D (25OHD).
the study includes 704 patients (573 women and 131 men). Mean age was 81±8 years (range 60-102). Severe pre-fracture disability was a common feature (58%) associated with multiple co-morbidities (84%), more frequently cardiovascular and neurological diseases, and specific medications. In a large proportion (86%) of the patients environmental or individual risk factors for falling were found. Vitamin D insufficiency was quite common, particularly in the regional Health Districts were strategies for preventing vitamin D deficiency were not implemented. Only a small proportion (17%) of the study population had been evaluate and treated for osteoporosis.
in senile patients with a recent hip fracture pre-existing disability, multiple co-morbidities, high risk of falling and inadequate intake of calcium and vitamin D was quite common. Community and case-finding interventions are highly warranted.
评估近期发生髋部骨折患者中最相关的环境和个体风险因素的患病率，这是由意大利威尼托大区卫生当局推动的这项观察性研究的目的。
对年龄大于60岁、近期发生髋部骨折且与恶性肿瘤无关的男女患者，发放关于饮食习惯、阳光暴露、残疾评分的问卷。收集完整的家族史、用药史和病史，以及既往跌倒情况、骨折指数详情、人体测量数据。在部分患者亚组中采集血液以测定血清25羟维生素D（25OHD）。
该研究纳入704例患者（573例女性和131例男性）。平均年龄为81±8岁（范围60 - 102岁）。骨折前严重残疾是常见特征（58%），与多种合并症（84%）相关，更常见的是心血管和神经系统疾病以及特定药物。在很大比例（86%）的患者中发现了跌倒的环境或个体风险因素。维生素D不足相当常见，尤其是在未实施预防维生素D缺乏策略的地区卫生区。仅一小部分（17%）的研究人群接受过骨质疏松症评估和治疗。
在近期发生髋部骨折的老年患者中，既往残疾、多种合并症、跌倒风险高以及钙和维生素D摄入不足相当常见。社区和病例发现干预措施非常必要。
