Sun Jun-Hui, Zhang Yue-Lin, Nie Chun-Hui, Chen Li-Ming, He Jian-DI, Wang Wei-Lin, Zheng Shu-Sen
Division of Hepatobiliary and Pancreatic Surgery, Key Laboratory of Combined Multi-organ Transplantation, Ministry of Public Health Key Laboratory of Organ Transplantation of Zhejiang Province; Department of Surgery, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, P.R. China.
Oncol Lett. 2012 May;3(5):975-977. doi: 10.3892/ol.2012.618. Epub 2012 Feb 28.
Advanced hepatocellular carcinoma (HCC) with invasion into the heart through the hepatic vein is a recognized rare occurrence with an extremely poor prognosis. Patients who present with right heart tumor thrombus have generally been considered inoperable. Although aggressive resection and liver transplantation treatment have previously been performed, the results remain unsatisfactory. However, HCC with extension into the heart usually indicates a contraindication for transcatheter arterial chemoembolization (TACE). In this study, a rare case of HCC with metastatic inferior vena cava (IVC) and right atrial (RA) tumor thrombus was reported. The young patient was admitted to our department due to Budd-Chiari syndrome. Following diagnosis according to CT image findings and laboratory data, the patient underwent TACE therapy. This treatment resulted in a marked reduction in the liver tumor and the right atrial tumor thrombus. Following TACE therapy, the patient survived for 3 years and 10 months and remains alive without any signs of recurrence. This case indicates that TACE therapy can be used successfully for the treatment of advanced HCC with heart tumor thrombus and may result in long-term survival.
晚期肝细胞癌(HCC)通过肝静脉侵犯心脏是一种公认的罕见情况,预后极差。出现右心肿瘤血栓的患者通常被认为无法进行手术。尽管此前曾进行过积极的切除和肝移植治疗,但结果仍不尽人意。然而,HCC侵犯心脏通常表明经导管动脉化疗栓塞术(TACE)存在禁忌。在本研究中,报告了一例罕见的伴有转移性下腔静脉(IVC)和右心房(RA)肿瘤血栓的HCC病例。该年轻患者因布加综合征入住我科。根据CT图像结果和实验室数据确诊后,患者接受了TACE治疗。该治疗使肝肿瘤和右心房肿瘤血栓明显缩小。TACE治疗后,患者存活了3年10个月,至今仍存活且无任何复发迹象。该病例表明,TACE治疗可成功用于治疗伴有心脏肿瘤血栓的晚期HCC,并可能实现长期生存。