Takamatsu Manabu, Aoki Hitomi, Hirose Yoshinobu, Kobayashi Kazuhiro, Tomita Hiroyuki, Kuno Toshiya, Koumura Hisashi, Hara Akira
Department of Tumor Pathology, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan.
Oncol Lett. 2012 May;3(5):1023-1026. doi: 10.3892/ol.2012.636. Epub 2012 Mar 6.
Teratoma is a tumor that forms triploblastic tissues and the common sites of occurrence are sacrococcygeal lesions and the ovaries. The majority of cases are curable with surgical resection and the prognosis depends on the extent and histological scoring of the tumor. In the present study, we report a case of sacrococcygeal teratoma of a newborn showing features of a retina-like structure. A 29-year-old woman gave birth prematurely to an infant girl with sacrococcygeal teratoma. Surgical resection was performed 10 days after delivery. The tumor contained immature components as well as a retina-like structure. Several investigations, including immunohistochemical analysis, confirmed the similarities between the normal mouse retina and the retina-like structure of the tumor. The vascular arrangement and polarity surrounding the retina-like structure are unique and this is thought to be significant in the induction of structural differentiation. Our findings may provide insights into the matter of teratogenic activity in stem cell therapies for clinical applications.
畸胎瘤是一种形成三胚层组织的肿瘤，常见发生部位是骶尾部病变和卵巢。大多数病例可通过手术切除治愈，预后取决于肿瘤的范围和组织学评分。在本研究中，我们报告了一例新生儿骶尾部畸胎瘤呈现视网膜样结构特征的病例。一名29岁女性早产下一名患有骶尾部畸胎瘤的女婴。分娩后10天进行了手术切除。肿瘤包含不成熟成分以及视网膜样结构。包括免疫组化分析在内的多项研究证实了正常小鼠视网膜与肿瘤的视网膜样结构之间的相似性。视网膜样结构周围的血管排列和极性是独特的，这被认为在结构分化的诱导中具有重要意义。我们的发现可能为临床应用的干细胞治疗中的致畸活性问题提供见解。
