Van Damme H, Damas P, David J L, Limet R
Department of Thoracic and Cardiovascular Surgery, University Hospital Sart-Tilman, Liège, Belgium.
Angiology. 1990 Dec;41(12):1075-81. doi: 10.1177/000331979004101209.
The authors report a case of heparin-induced thrombocytopenia, in whom massive pulmonary embolism occurred in spite of heparin anticoagulation. Successful pulmonary thrombectomy was carried out under cardiopulmonary bypass, with limitation of platelet clumping during bypass by aggregation inhibitors. This report is a comprehensive contribution to a better understanding of this rare immunoallergic complication of heparin administration, with a high incidence of serious thromboembolic events. The optimal management for cases of unavoidable reexposure to heparin is discussed.
作者报告了一例肝素诱导的血小板减少症病例，尽管进行了肝素抗凝治疗，但该患者仍发生了大面积肺栓塞。在体外循环下成功实施了肺动脉血栓切除术，并使用聚集抑制剂限制体外循环期间的血小板聚集。本报告为更好地理解肝素给药这一罕见的免疫过敏并发症做出了全面贡献，该并发症严重血栓栓塞事件的发生率很高。文中还讨论了不可避免再次接触肝素病例的最佳管理方法。
