Department of Medical Research, Holstebro Hospital, Holstebro, Denmark.
Clin Exp Hypertens. 2013;35(2):148-57. doi: 10.3109/10641963.2012.702835. Epub 2012 Jul 11.
Statin treatment improves endothelial function but the effects of statins on renal nitric oxide have not been clarified. In this crossover study, 26 healthy subjects received atorvastatin 80 mg per day or placebo for 5 days. After 5 days of treatment, L-N(G)-monomethyl arginine caused a similar increase in blood pressure and decrease in urine output and glomerular filtration rate. The decrease in fractional excretion of sodium to L-N(G)-monomethyl arginine was more pronounced after atorvastatin treatment. Atorvastatin did not change the response to several vasoactive hormones. The results indicate that atorvastatin increase renal nitric oxide, which may explain a part of the pleiotropic effects of statins.
他汀类药物治疗可改善血管内皮功能，但他汀类药物对肾脏一氧化氮的影响尚未阐明。在这项交叉研究中，26 名健康受试者每天服用阿托伐他汀 80mg 或安慰剂 5 天。治疗 5 天后，L-N(G)-单甲基精氨酸引起相似的血压升高和尿量及肾小球滤过率降低。阿托伐他汀治疗后，L-N(G)-单甲基精氨酸的钠排泄分数降低更为明显。阿托伐他汀治疗并未改变对几种血管活性激素的反应。结果表明，阿托伐他汀增加了肾脏一氧化氮，这可能解释了他汀类药物的部分多效性作用。
