健康正常肾脏的肾水分子扩散特性：磁共振扩散张量成像评估
Renal water molecular diffusion characteristics in healthy native kidneys: assessment with diffusion tensor MR imaging.
作者信息
Zheng Zhenfeng, Shi Huilan, Zhang Jing, Zhang Yunting
机构信息
Department of Nephrology, General Hospital of Tianjin Medical University, Heping District, Tianjin, China.
Department of Radiology, General Hospital of Tianjin Medical University, Heping District, Tianjin, China.
出版信息
PLoS One. 2014 Dec 3;9(12):e113469. doi: 10.1371/journal.pone.0113469. eCollection 2014.
BACKGROUND
To explore the characteristics of diffusion tensor imaging (DTI) and magnetic resonance (MR) imaging in healthy native kidneys.
METHODS
Seventy-three patients without chronic kidney disease underwent DTI-MRI with spin echo-echo planar (SE-EPI) sequences accompanied by an array spatial sensitivity encoding technique (ASSET). Cortical and medullary mean, axial and radial diffusivity (MD, AD and RD), fractional anisotropy (FA) and primary, secondary and tertiary eigenvalues (λ1, λ2, λ3) were analysed in both kidneys and in different genders.
RESULTS
Cortical MD, λ2, λ3, and RD values were higher than corresponding medullary values. The cortical FA value was lower than the medullary FA value. Medullary λ1 and RD values in the left kidney were lower than in the right kidney. Medullary λ2, and λ3 values in women were higher than those in men. Medullary FA values in women were lower than those in men. Medullary FA (r = 0.351, P = 0.002) and λ1 (r = 0.277, P = 0.018) positively correlated with eGFR. Medullary FA (r = -0.25, P = 0.033) negatively correlated with age.
CONCLUSIONS
Renal water molecular diffusion differences exist in human kidneys and genders. Age and eGFR correlate with medullary FA and primary eigenvalue.
背景
探讨健康正常肾脏的扩散张量成像（DTI）和磁共振（MR）成像特征。
方法
73例无慢性肾脏病患者采用自旋回波-回波平面成像（SE-EPI）序列联合阵列空间敏感编码技术（ASSET）进行DTI-MRI检查。分析双肾及不同性别患者皮质和髓质的平均扩散率、轴向扩散率和径向扩散率（MD、AD和RD）、分数各向异性（FA）以及第一、第二和第三本征值（λ1、λ2、λ3）。
结果
皮质MD、λ2、λ3和RD值高于相应的髓质值。皮质FA值低于髓质FA值。左肾髓质λ1和RD值低于右肾。女性髓质λ2和λ3值高于男性。女性髓质FA值低于男性。髓质FA（r = 0.351，P = 0.002）和λ1（r = 0.277，P = 0.018）与估算肾小球滤过率（eGFR）呈正相关。髓质FA（r = -0.25，P = 0.033）与年龄呈负相关。
结论
人类肾脏在性别间存在水分子扩散差异。年龄和eGFR与髓质FA及第一本征值相关。
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