Tasso Cereceda M J, Ferris Tortajada J, Cañete Nieto A, Hernández Martí M, Verdeguer Miralles A, Esquembre Menor C, Castel Sánchez V
Unidad Oncología Pediátrica, Hospital Infantil La Fe, Valencia.
An Esp Pediatr. 1990 Oct;33(4):343-8.
Thirty-two children with retinoblastoma (RTB) were treated in our oncology unit between September 1981 and October 1989. There were 18 unilateral RTB and 14 bilateral. The median age at diagnosis was 24 months. Leukocoria was the most common sign of presentation (66%). All patients were treated with a protocol based on Reese-Ellsworth classification and the anatomo-clinic extension. Thirty patients were enucleated (7 bilaterally), 14 of which needed coadjuvant chemotherapy and 6 orbital radiotherapy. Two patients died, one from each group. The disease-free survival rate is 90.6% with a medium follow-up of 43.5 months. Seven children went blind because of bilateral enucleation and seven present facial deformity caused by radiotherapy. We underline the importance of improving the effectiveness of conservative treatment in order to reduce the number of enucleation.
1981年9月至1989年10月期间，我们肿瘤科室收治了32例视网膜母细胞瘤（RTB）患儿。其中18例为单侧视网膜母细胞瘤，14例为双侧。诊断时的中位年龄为24个月。白瞳症是最常见的表现体征（66%）。所有患者均按照基于里斯 - 埃尔斯沃思分类法及解剖临床分期的方案进行治疗。30例患者接受了眼球摘除术（7例为双侧），其中14例需要辅助化疗，6例需要眼眶放疗。2例患者死亡，每组各1例。中位随访43.5个月时，无病生存率为90.6%。7名儿童因双侧眼球摘除而失明，7名儿童因放疗导致面部畸形。我们强调提高保守治疗效果以减少眼球摘除数量的重要性。
