Respiratory Diseases Department of the Chinese PLA General Hospital, Beijing, China.
Lung Cancer. 2012 Oct;78(1):45-50. doi: 10.1016/j.lungcan.2012.06.004. Epub 2012 Jul 10.
Solitary thin-walled cavity lung cancer is a specific form of lung cancer, the diagnosis of which remains a formidable challenge.
By comparing the computed tomography (CT) presentations and pathological findings, the purpose of present study was to explain the possible mechanism of thin-walled cavity formation and to improve the diagnostic accuracy for this disease.
The medical records of eighteen patients with solitary thin-walled cavity lung cancer were analyzed retrospectively.
Chest CT demonstrated that solitary thin-walled cavities located at pulmonary periphery, and all these cavity lesions displayed suspected malignant signs. Pathological findings after surgery confirmed these lesions were adenocarcinoma, most of which were moderately or well differentiated. Microscopic findings showed tumor cells proliferated in the surface of thin-wall cavity in nine patients and infringed bronchiolar wall in five patients. No obvious necrotic tumor cell was observed in each patient.
It was suggested some thin-walled cavities may be formed as a result of unidirectional check-valve mechanism. Together, a high index of awareness of this suspected CT signs is required for early diagnosis of this disease.
孤立性薄壁空洞型肺癌是一种特殊类型的肺癌，其诊断仍然是一个巨大的挑战。
通过比较 CT 表现和病理结果，本研究旨在解释薄壁空洞形成的可能机制，并提高对该病的诊断准确性。
回顾性分析 18 例孤立性薄壁空洞型肺癌患者的病历资料。
胸部 CT 显示，孤立性薄壁空洞位于肺外周，所有这些空洞病变均显示出疑似恶性的征象。手术后的病理结果证实这些病变均为腺癌，其中大多数为中或高分化。镜下观察发现，9 例患者的薄壁空洞表面有肿瘤细胞增殖，5 例患者侵犯了细支气管壁。每个患者均未见明显坏死的肿瘤细胞。
提示某些薄壁空洞可能是由于单向活瓣机制形成的。总之，对这种疑似 CT 征象的高度认识有助于早期诊断该病。
