心脏手术术后纵隔炎的治疗结果；负压伤口治疗与传统治疗的对比
Treatment outcomes of postoperative mediastinitis in cardiac surgery; negative pressure wound therapy versus conventional treatment.
作者信息
Deniz Hayati, Gokaslan Gokhan, Arslanoglu Yavuz, Ozcaliskan Ozerdem, Guzel Gokalp, Yasim Alptekin, Ustunsoy Hasim
机构信息
Gaziantep University Medical Faculty, Department of Cardiovascular Surgery, Sehitkamil, Gaziantep, Turkey.
出版信息
J Cardiothorac Surg. 2012 Jul 11;7:67. doi: 10.1186/1749-8090-7-67.
BACKGROUND
The aim of the present study is to compare negative pressure wound therapy versus conventional treatment outcomes at postoperative mediastinitis after cardiac surgery.
METHODS
Between January 2000 and December 2011, after 9972 sternotomies, postoperative mediastinitis was diagnosed in 90 patients. The treatment modalities divided the patients into two groups: group 1 patients (n = 47) were initially treated with the negative pressure wound therapy and group 2 patients (n = 43) were underwent conventional treatment protocols. The outcomes were investigated with Kaplan-Meier method, log-rank test, Student's test and Fisher's exact test.
RESULTS
The 90-days mortality was found significantly lower in the negative pressure wound group than in the conventionally treated group. Overall survival was significantly better in the negative pressure wound group than in the conventionally treated group.
CONCLUSION
Negative pressure wound therapy is safe and reliable option in mediastinitis after cardiac surgery, with excellent survival and low failure rate when compared with conventional treatments.
背景
本研究旨在比较心脏手术后纵隔炎患者负压伤口治疗与传统治疗的效果。
方法
2000年1月至2011年12月期间，9972例行胸骨切开术后，90例患者被诊断为术后纵隔炎。治疗方式将患者分为两组：第1组患者（n = 47）最初接受负压伤口治疗，第2组患者（n = 43）接受传统治疗方案。采用Kaplan-Meier法、对数秩检验、学生检验和Fisher精确检验对结果进行研究。
结果
发现负压伤口组90天死亡率显著低于传统治疗组。负压伤口组的总体生存率显著优于传统治疗组。
结论
与传统治疗相比，负压伤口治疗是心脏手术后纵隔炎安全可靠的选择，生存率高且失败率低。
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