Department of Ophthalmic Oncology, Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Surv Ophthalmol. 2012 Nov;57(6):558-64. doi: 10.1016/j.survophthal.2012.02.004. Epub 2012 Jul 10.
Traditionally, the paraneoplastic retinopathies have been classified into two groups: melanoma-associated retinopathy (MAR) and cancer-associated retinopathy. MAR occurs in individuals with metastatic cutaneous or uveal melanoma and is characterized by nyctalopia, photopsias, and variable vision loss. In most cases, the fundus is essentially normal in appearance. More recently, there have been multiple reports of a MAR-like retinopathy with associated detachments of the retinal pigment epithelium and neurosensory retina. Such a clinical presentation has been termed paraneoplastic vitelliform retinopathy. We describe an 80-year-old man with metastatic cutaneous melanoma who developed paraneoplastic vitelliform retinopathy. For the first time, histopathology from enucleation specimens provides a clinicopathologic disease correlation with focal abnormalities in the inner nuclear and outer plexiform layers.
传统上，副肿瘤性视网膜病变分为两类：黑色素瘤相关视网膜病变（MAR）和癌症相关视网膜病变。MAR 发生在患有转移性皮肤或葡萄膜黑色素瘤的个体中，其特征是夜盲、光幻视和视力不同程度的丧失。在大多数情况下，眼底外观基本正常。最近，有多项报告称存在一种 MAR 样视网膜病变，伴有视网膜色素上皮和神经感觉层的脱离。这种临床表现被称为副肿瘤性类黄色瘤性视网膜病变。我们描述了一名 80 岁男性，患有转移性皮肤黑色素瘤，出现副肿瘤性类黄色瘤性视网膜病变。首次通过眼球摘除标本的组织病理学提供了临床病理疾病相关性，在内核层和外丛状层有局灶性异常。
