Vamvakidès A
Laboratoire Chropi, Paris.
Ann Pharm Fr. 1990;48(3):154-9.
Three GABA derivatives, the GABA-steatamide (GS), the GABA-linoleamide (GL) and the progabide, two glycine derivatives, the glycine-steatamide (SG) and the glycine-linoleamide (LG) and, lastly, a glutamic acid derivative, the glutamic acid palmitamide (PGt), were studied in the forced swimming test (Porsolt's test) on mice. The anti-immobility effect, referring to the existence of antidepressive properties, was significant for the SG, LG, GL and PGt. It seems that the relative intensity of the anti-immobility effect on the one hand and the sedative properties on the other, could operate on the experimental profile of these derivatives in the Porsolt's test.
在小鼠强迫游泳试验（波索尔特试验）中，对三种γ-氨基丁酸衍生物，即γ-氨基丁酸硬脂酰胺（GS）、γ-氨基丁酸亚油酰胺（GL）和普罗加比，两种甘氨酸衍生物，即甘氨酸硬脂酰胺（SG）和甘氨酸亚油酰胺（LG），以及最后一种谷氨酸衍生物，即谷氨酸棕榈酰胺（PGt）进行了研究。就抗抑郁特性的存在而言，SG、LG、GL和PGt的抗不动效应显著。在波索尔特试验中，这些衍生物的实验概况似乎一方面取决于抗不动效应的相对强度，另一方面取决于镇静特性。
