Vamvakidès A
J Pharmacol. 1986 Jul-Sep;17(3):323-7.
We have studied the effect of GABA-linoleamide (GL) (100 mg/kg i.p.) and glycine-linoleamide (LG) (70 mg/kg i.p.), on the pentamethylenetetrazole (PTZ) (82 mg/kg i.p.) convulsions and lethality of rats. LG antagonize more efficiently than GL the PTZ convulsions and lethality. In another experiment, rats have received haloperidol (2 mg/kg i.p.) for 12 days. Four days after the last administration of haloperidol, rats received as previously GL (100 mg/kg i.p.) or LG (70 mg/kg i.p.) and PTZ (82 mg/kg i.p.). GL only antagonized the PTZ convulsions and lethality. The above results seem to demonstrate the importance of GABA-ergic and glycinergic receptors in the control of PTZ convulsions and they are supported by the recent data on the role of the inhibiting neuromediators, GABA and glycine, in the substantia nigra.
我们研究了γ-氨基丁酸-亚油酰胺（GL）（腹腔注射100毫克/千克）和甘氨酸-亚油酰胺（LG）（腹腔注射70毫克/千克）对大鼠戊四氮（PTZ）（腹腔注射82毫克/千克）惊厥和致死率的影响。LG比GL更有效地拮抗PTZ惊厥和致死率。在另一项实验中，大鼠连续12天接受氟哌啶醇（腹腔注射2毫克/千克）。在最后一次给予氟哌啶醇4天后，大鼠如先前一样接受GL（腹腔注射100毫克/千克）或LG（腹腔注射70毫克/千克）以及PTZ（腹腔注射82毫克/千克）。GL仅拮抗PTZ惊厥和致死率。上述结果似乎表明γ-氨基丁酸能和甘氨酸能受体在控制PTZ惊厥中的重要性，并且近期关于抑制性神经递质γ-氨基丁酸和甘氨酸在黑质中作用的数据也支持了这一点。
