Khalil M A, Habib N S
Pharmaceutical Chemistry Department, Faculty of Pharmacy, University of Alexandria, Egypt.
Arch Pharm (Weinheim). 1990 Aug;323(8):471-4. doi: 10.1002/ardp.19903230806.
Two novel series of quinone derivatives have been synthesized. Thus, condensation of 2-ethoxycarbonylmethylthio-; 3-ethoxycarbonylmethylthio-2-methyl- and 3-ethoxycarbonylmethoxy-2-methyl derivatives of 1,4-naphthoquinone with substituted phenylhydrazines afforded the corresponding hydrazones, while cyclization of the same quinones with the same substituted hydrazines in glacial acetic acid gave the corresponding naphtho[2,1-b]-1,4,5-oxa- or thiadiazepine derivatives. The antimicrobial and anticancer activities of the synthesized compounds were studied.
已经合成了两个新型的醌衍生物系列。因此，1,4-萘醌的2-乙氧羰基甲基硫代、3-乙氧羰基甲基硫代-2-甲基和3-乙氧羰基甲氧基-2-甲基衍生物与取代苯肼缩合得到相应的腙，而相同的醌与相同的取代肼在冰醋酸中环化得到相应的萘并[2,1-b]-1,4,5-恶二氮杂卓或噻二氮杂卓衍生物。研究了合成化合物的抗菌和抗癌活性。
